A systemic lymphoproliferative disorder with morphologic features of Castlemanʼs disease

Frizzerà, Glauco; Massarelli, Giovannino; Banks, Peter M.; Rosaí, Juan

doi:10.1097/00000478-198304000-00001

Cited by 276 publications

(54 citation statements)

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“…2,3 The incidence of malignancies, in particular lymphoma and Kaposi's sarcoma, has already been reported in patients with multicentric Castleman's disease. 4,5 The association between unicentric Castleman's disease and vascular neoplasm has also been described previously. 6 Optimal therapy remains uncertain, but most reports describing surgical resection indicate that complete resection is curative for unicentric Castleman's disease.…”

Section: Discussionmentioning

confidence: 56%

“…In contrast, the plasma cell variant is frequently associated with various signs and symptoms such as hypergammaglobulinemia, elevated ESR, anemia and pyrexia. [2][3][4] Furthermore, both variants can be either unicentric or multicentric. Multicentric forms may display a more aggressive course and have frequently been associated with infectious complications.…”

Section: Discussionmentioning

confidence: 99%

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Unicentric Castleman's disease with leiomyosarcoma: A rare association

et al. 2003

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A 54-year-old asymptomatic woman was first diagnosed with unicentric Castleman's disease at 51 years of age. The disease was identified incidentally behind the inferior vena cava after a computed tomography (CT) scan. She was followed conservatively and no enlargement of the mass was observed. However, a follow-up CT scan revealed another solid mass in the left retroperitoneal area. Both tumors were surgically removed in the same session. The retrocaval mass was histologically confirmed to be Castleman's disease of the hyaline vascular type. Histological examination of the left peritoneal mass revealed low-grade leiomyosarcoma. We present here a case of leiomyosarcoma associated with unicentric Castleman's disease, both of which were localized in the retroperitoneum.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Unicentric Castleman's disease with leiomyosarcoma: A rare association

et al. 2003

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“…The former was characterized by a recognizable lymph node architecture, hyperplastic germinal centers, and intervening sheets of plasma cells, the latter by abnormal germinal centers and abundant hyalinized vessels. After the publication of these reports a multicentric lymphoproliferative disorder with systemic symptoms and morphological features of the plasma-cell type was described [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…High dose corticosteroids have resulted in long lasting remissions [13,29]. Chemotherapy regimens, consisting of a single agent or combination treatment, often showed only poor response rates [14].…”

Section: Introductionmentioning

confidence: 99%

A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects

Veldhuis

Leest²,

Wolf

et al. 1996

Annals of Hematology

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A patient is presented who had Castleman's disease with constitutional symptoms, a palpable supraclavicular/ axillar mass, and a microcytic anemia, among other laboratory abnormalities, including elevated levels of interleukin-6. Treatment consisted of irradiation of the involved area, with subsequent disappearance of all symptoms and normalization of the laboratory abnormalities. Iron kinetic studies demonstrated a hypoproliferative erythropoiesis, which normalized after radiotherapy. Hypoproliferative erythopoiesis could not be ascribed to serum inhibitors, since normal burst-forming units were observed in the absence or presence of autologous serum. The role of interleukin-6 in relation to Castleman's disease is highlighted.

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“…giant lymph node hyperplasia ; ascites ; monoclonal gammopathy ; double cancer Multicentric giant lymph node hyperplasia (MGLNH) is recently described as a systemic lymphoproliferative disorder with histological similarities to giant lymph node hyperplasia (GLNH) or Castleman's disease (Frizzera et al 1983;Tanda et al 1983). GLNH is most commonly mediastinal and has essentially a benign process.…”

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confidence: 99%