A systemic review on tuberculosis

Natarajan, A.T.; Beena, P M; Devnikar, Anushka V.; Mali, Sagar

doi:10.1016/j.ijtb.2020.02.005

Cited by 207 publications

(146 citation statements)

References 34 publications

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“…Although it can affect any organ or anatomical part, it is distributed as follows: lymph nodes (47%), pleural cavity (30%), abdomen (10%), bones and joints (8%), central nervous system (82%), and others (3%) [1].…”

Section: Discussionmentioning

confidence: 99%

“…Mycobacterium tuberculosis is an aerobic, non-spore-forming bacterium, and the etiological cause of tuberculosis, with the lungs being the most common localization of the disease [ 1 ]. Bronchial stenosis is infrequent in pulmonary tuberculosis and usually affects small bronchi, and the involvement of the main bronchus is usually associated with tracheobronchial tuberculosis, a poorly recognized and underdiagnosed entity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Main Bronchus Stenosis Due to Tuberculosis and Ogilvie’s Syndrome: A Case Report of Two Unusual Diseases in the Same Patient

Pinzon¹,

Condoy²,

Fonseca³

et al. 2021

Cureus

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Main bronchus stenosis as a sequel of pulmonary tuberculosis is infrequent and should raise suspicion of other presentations of the infection. Given its non-specific symptomatology and the absence of a specific diagnostic method, tracheobronchial tuberculosis is usually not suspected and diagnosed despite its great impact on quality of life due to the high incidence of stenosis as a consequence. Ogilvie's syndrome, an uncommon condition, requires careful management and surveillance given the risk of ischemia and colonic perforation intrinsic to the disease. We present a case of a patient with main bronchus stenosis secondary to tuberculosis infection and Ogilvie's syndrome post-surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Main Bronchus Stenosis Due to Tuberculosis and Ogilvie’s Syndrome: A Case Report of Two Unusual Diseases in the Same Patient

Pinzon¹,

Condoy²,

Fonseca³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…Tuberculosis is caused by the Mycobacterium tuberculosis that could transmit among humans via the respiratory route. As one of the ancient human diseases, tuberculosis is still one of the leading causes of death among all infectious diseases ( Bloom et al, 2017 ; Natarajan et al, 2020 ), but clinical treatment is usually accompanied by a high incidence of INH-induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

Zhang

et al. 2021

Front. Mol. Biosci.

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Isoniazid (INH), an effective first-line drug for tuberculosis treatment, has been reported to be associated with hepatotoxicity for decades, but the underlying mechanisms are poorly understood. N-acetyltransferase 2 (NAT2) is a Phase II enzyme that specifically catalyzes the acetylation of INH, and NAT2 expression/activity play pivotal roles in INH metabolism, drug efficacy, and toxicity. In this study, we systematically investigated the regulatory roles of microRNA (miRNA) in NAT2 expression and INH-induced liver injury via a series of in silico, in vitro, and in vivo analyses. Four mature miRNAs, including hsa-miR-15a-3p, hsa-miR-628-5p, hsa-miR-1262, and hsa-miR-3132, were predicted to target the NAT2 transcript, and a negative correlation was observed between hsa-miR-15a-3p and NAT2 transcripts in liver samples. Further experiments serially revealed that hsa-miR-15a-3p was able to interact with the 3′-untranslated region (UTR) of NAT2 directly, suppressed the endogenous NAT2 expression, and then inhibited INH-induced NAT2 overexpression as well as INH-induced liver injury, both in liver cells and mouse model. In summary, our results identified hsa-miR-15a-3p as a novel epigenetic factor modulating NAT2 expression and as a protective module against INH-induced liver injury, and provided new clues to elucidate the epigenetic regulatory mechanisms concerning drug-induced liver injury (DILI).

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“…Its most common manifestation is pulmonary tuberculosis however it can potentially affect any organ [1]. Tuberculosis is the leading cause of death worldwide from an infectious disease among adults and has been associated with poverty [2]. The disease's incidence is highest in low-income countries and its burden is also primarily borne by the most socio-economically deprived communities.…”

Section: Introductionmentioning

confidence: 99%

“…The disease's incidence is highest in low-income countries and its burden is also primarily borne by the most socio-economically deprived communities. [2]. Portugal has been an oddity in southwestern Europe concerning tuberculosis incidence.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Tuberculosis With Cardiac Tamponade in an Immunocompetent Individual

Bibi¹,

Monteiro²,

Oliveira³

et al. 2021

Cureus

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A systemic review on tuberculosis

Cited by 207 publications

References 34 publications

Main Bronchus Stenosis Due to Tuberculosis and Ogilvie’s Syndrome: A Case Report of Two Unusual Diseases in the Same Patient

Main Bronchus Stenosis Due to Tuberculosis and Ogilvie’s Syndrome: A Case Report of Two Unusual Diseases in the Same Patient

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

Disseminated Tuberculosis With Cardiac Tamponade in an Immunocompetent Individual

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