2014
DOI: 10.1158/0008-5472.can-13-2275
|View full text |Cite
|
Sign up to set email alerts
|

A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma

Abstract: The complex interactions between cancer cells and their surrounding stromal microenvironment play important roles in tumor initiation and progression and represent viable targets for therapeutic intervention. Here, we propose a concept of common target perturbation (CTP). CTP acts simultaneously on the same target in both the tumor and its stroma that generates a bilateral disruption for potentially improved cancer therapy. To employ this concept, we designed a systems biology strategy by combining experiment … Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
33
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 33 publications
(33 citation statements)
references
References 40 publications
0
33
0
Order By: Relevance
“…42 The complex cross-talk between the tumor and its surrounding stroma has been recognized as important promoter for the refractory of cancers. 43 MDSCs may act as a bridge to connect this cross-talk.…”
Section: Discussionmentioning
confidence: 99%
“…42 The complex cross-talk between the tumor and its surrounding stroma has been recognized as important promoter for the refractory of cancers. 43 MDSCs may act as a bridge to connect this cross-talk.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, there is evidence that components of the tumor stroma critically influence carcinogenesis and the malignant phenotype in multiple stages of tumor development and progression 18,19 . The complex interactions among tumor cells and the various types of cells and matrix components within the microenvironment play important roles in cancer onset, progression, invasion, and metastasis 20,21 .…”
Section: Introductionmentioning
confidence: 99%
“…To obtain LKAFs, carcinoma-associated fibroblasts (CAFs), and normal fibroblasts (NFs), the tissues were isolated, cultured, and purified using previously described protocols (Liu et al, 2006; Meng et al, 2014). The collected tissues were cut into pieces and cultured in Dulbecco's modified Eagle's medium (DMEM; GIBCO, Thermo Fisher Scientific Inc., Waltham, MA, USA) with 10% fetal bovine serum (GIBCO) at 37°C with 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…Western blotting was performed as described previously (Meng et al, 2014). Cells were lysed in lysis buffer (Keygen Biotech Inc., Nanjing, China) and 30 μg of the total proteins were loaded for each sample.…”
Section: Methodsmentioning
confidence: 99%