A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

Liu, Jianling; Pei, Mengjie; Zheng, Chunli; Yan, Li; Wang, Yonghua; Lü, Aiping; Yang, Ling

doi:10.1155/2013/938764

Cited by 60 publications

(40 citation statements)

References 87 publications

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“…This systems/network pharmacology methodology has been successfully applied to dissect basic TCM theories such as yin-yang theory [9], qi-blood [5], herbal synergy [10,11], as well as to develop new drugs [7]. However, systems pharmacology, as a novel holistic, a multi-disciplinary, integrative field, is still difficult to be widely applied.…”

Section: Introductionmentioning

confidence: 99%

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

et al. 2014

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BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate the drug discovery from herbal medicines, an efficient systems pharmacology platform that represents ideal information convergence of pharmacochemistry, ADME properties, drug-likeness, drug targets, associated diseases and interaction networks, are urgently needed.DescriptionThe traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) was built based on the framework of systems pharmacology for herbal medicines. It consists of all the 499 Chinese herbs registered in the Chinese pharmacopoeia with 29,384 ingredients, 3,311 targets and 837 associated diseases. Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski’s rule of five are provided for drug screening and evaluation. TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. It is designed to fuel the development of herbal medicines and to promote integration of modern medicine and traditional medicine for drug discovery and development.ConclusionsThe particular strengths of TCMSP are the composition of the large number of herbal entries, and the ability to identify drug-target networks and drug-disease networks, which will help revealing the mechanisms of action of Chinese herbs, uncovering the nature of TCM theory and developing new herb-oriented drugs. TCMSP is freely available at http://sm.nwsuaf.edu.cn/lsp/tcmsp.php.

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Section: Introductionmentioning

confidence: 99%

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

et al. 2014

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“…Pseudostellaria heterophylla (Miquel) Pax has been described as a type of ‘qi-enriching and tonic drug’ (6), which has a beneficial effect for the immune system (7). In addition, Pseudostellaria heterophylla (PH) has mild toning effects on the body, leading to its widespread use in herbal medicines and healthcare products (8,9).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis

Choi

Kim

Ahn

et al. 2016

Molecular Medicine Reports

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Pseudostellaria heterophylla (PH) has various pharmacological effects that include immunologic enhancement and anti-oxidation. However, it remains unclear whether PH exerts beneficial effects in dermatological diseases. The present study examined the effects of PH on a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mouse model and elucidated its underlying mechanism of action. PH extract (1 and 100 mg/ml) was applied topically to DNCB-treated dorsal skin of mice every day for 11 days. The immunomodulatory effects of PH were evaluated by measuring skin thickness, mast cell infiltration, serum levels of immunoglobulin E (IgE), and mRNA expression levels of T helper (h)1/Th2 and pro-inflammatory cytokines in dorsal skin. In addition, cluster of differentiation (CD)4+ T cells were detected in dorsal skin by immunohistochemistry. Topical application of PH significantly reduced the thickness of dermis, epidermis and serum IgE production compared with the DNCB group. PH treatment inhibited infiltration of inflammatory cells, including mast cells and CD4+ T cells, and suppressed the mRNA expression levels of cytokines (interferon-γ, interleukin-4, −6, −8 and −1β, and tumor necrosis factor-α) associated with the immune response. Furthermore, PH treatment significantly downregulated the protein expression levels of nuclear factor-κB, phosphorylated inhibitor of κBα and mitogen-activated protein kinases. The results suggested that PH may be a potential therapeutic strategy for the treatment of AD via the modulation of Th1 and Th2 levels.

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“…Large batch‐to‐batch variation in HDS product content is common. ( 107‐110 ) The U.S. DILIN using toxicologic analysis confirmed the suspicion of supplement mislabeling in multi‐ingredient products, with rates up to 50%‐80%. ( 111 ) The potential for more severe liver injury with these products remains largely unknown.…”

Section: Hds‐induced Liver Injurymentioning

confidence: 94%

Drug‐Induced Liver Injury in GI Practice

Sandhu

Navarro

2020

Hepatol Commun

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Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug-related and herbal and dietary supplement-related liver injury. In this review, we discuss what defines liver injury, epidemiology of DILI, its biochemical and pathologic patterns, and management. (Hepatology Communications 2020;4:631-645). and Kidney Diseases established the U.S. DILI Network (DILIN) in 2003 to identify, enroll, and characterize cases of non-APAP DILI and herbal and dietary supplements (HDSs). (13) The U.S. DILIN has two registry studies at eight different academic centers across the United States. The network has expanded our understanding of DILI. Antimicrobials were noted to be the most common causative agents, accounting for 45% of cases in a 2004 study, followed by HDSs, cardiovascular drugs, central nervous system agents, antineoplastic agents, and analgesics. (14) Of the antimicrobials, amoxicillin-clavulanate (22%), isoniazid (11.7%), and nitrofurantoin (10.2%) were the top three implicated agents. (14) The network has also noted an increasing proportion of HDS-related liver injury,

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A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

Cited by 60 publications

References 87 publications

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis

Drug‐Induced Liver Injury in GI Practice

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