A table for the estimation of the spontaneous mutations rate of cells in culture

Capizzi, Robert L.; Jameson, Johnson W.

doi:10.1016/0027-5107(73)90265-0

Cited by 138 publications

(63 citation statements)

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“…Mutation rates and the calculated value for the ratio of the SD to the mean were determined by using equations 8 and 12, respectively, of Luria and Delbrü ck (41). Values for the expression CaN t were obtained from the numerical tables of Capizzi and Jameson (52).…”

Section: Discussionmentioning

confidence: 99%

High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6

Chen

Bigner

Modrich

2001

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6

Chen

Bigner

Modrich

2001

Proc. Natl. Acad. Sci. U.S.A.

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“…LacZ ϩ cells are visualized upon histochemical staining that detects the encoded ␤-GAL activity. Recombination rates were calculated using tables for the estimation of spontaneous mutation rates according to Luria & Delbrü ck (Capizzi and Jameson, 1972).…”

Section: Determination Of Intrachromosomal Recombination Ratesmentioning

confidence: 99%

The YeastTEL1Gene Partially Substitutes for HumanATMin Suppressing Hyperrecombination, Radiation-Induced Apoptosis and Telomere Shortening in A-T Cells

Fritz¹,

Friedl²,

Zwacka

et al. 2000

MBoC

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Homozygous mutations in the human ATM gene lead to a pleiotropic clinical phenotype of ataxia-telangiectasia (A-T) patients and correlating cellular deficiencies in cells derived from A-T donors. Saccharomyces cerevisiae tel1 mutants lacking Tel1p, which is the closest sequence homologue to the ATM protein, share some of the cellular defects with A-T. Through genetic complementation of A-T cells with the yeast TEL1 gene, we provide evidence that Tel1p can partially compensate for ATM in suppressing hyperrecombination, radiation-induced apoptosis, and telomere shortening. Complementation appears to be independent of p53 activation. The data provided suggest that TEL1 is a functional homologue of human ATM in yeast, and they help to elucidate different cellular and biochemical pathways in human cells regulated by the ATM protein.

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“…The frequencies determined HR rate as described. 39 The student t test was performed to measure the statistical significance of differences in the HR rate between p53-positive and p53-neagtive cell clones.…”

Section: Dna Manipulationsmentioning

confidence: 99%