A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population

Abstract

SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the effects of SIRT1 variants on MI risk remain poorly understood. Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI. Genotyping of three tagSNPs (rs7069102, rs3818292 and rs4746720) in SIRT1 gene was performed in a Chinese Han population, consisting of 287 MI cases and 654 control subjects. In a logistic regression analysis, we found that G allele of rs7069102 had increased MI risk with odds ratio (OR) of 1.57 [95% confidence interval (CI) = 1.15–2.16, Bonferroni corrected P (Pc) = 0.015] after adjustment for conventional risk factors compared to C allele. Similarly, the combined CG/GG genotypes was associated with the increased MI risk (OR = 1.64, 95% CI = 1.14–2.35, Pc = 0.021) compared to the CC genotype. Further stratified analysis revealed a more significant association with MI risk among younger subjects (≤ 55 years old). Consistent with these results, the haplotype rs7069102G-rs3818292A-rs4746720T containing the rs7069102 G allele was also associated with the increased MI risk (OR = 1.41, 95% CI = 1.09–1.84, Pc = 0.040). However, we did not detect any association of rs3818292 and rs4746720 with MI risk. Our study provides the first evidence that the tagSNP rs7069102 and haplotype rs7069102G-rs3818292A-rs4746720T in SIRT1 gene confer susceptibility to MI in the Chinese Han population.

Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

“…There was no statistically significant difference between the MI cases and controls in terms of age. Traditional MI risk factors were prevalent, as we previously reported [3]. In the comparison of lipid profiles, serum triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC) were higher in the patients than in the controls ( P < 0.001, P = 0.226, P < 0.001, respectively), whereas serum high density lipoprotein cholesterol (HDLC) levels were significantly higher among controls ( P < 0.001).…”

“…Increasing evidences have revealed that genetic polymorphisms in candidate genes are associated with the risk of MI [3–6]. …”

Association oflincRNA-p21Haplotype with Coronary Artery Disease in a Chinese Han Population

“…All study individuals were genetically unrelated Han Chinese. Inclusion and exclusion criteria, diagnosis, and evaluation as well as criteria for CAD, MI, and controls were described previously [ 4 , 26 ].…”

“…Hypertension was defined if the individual's systolic and/or diastolic blood pressure (DBP) was above 140/90 mmHg [ 29 ]. Diabetes mellitus, dyslipidemia, and smoking were defined as described in our previous study [ 26 ]. This study was approved by the Ethics Committee of the Affiliated Hospital of Guangdong Medical University and the First People's Hospital of Foshan.…”

Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes

“…In the current obesity/diabetes epidemic caffeine metabolism is possibly defective [18] and effects of caffeine is via Sirt 1/p53 regulated mitochondria biogenesis with caffeine doses related to p53 mediated mitophagy relevant to cellular programmed cell death [17]. Sirt 1 is relevant to mitophagy [17][18][19][20] in myocardial infarction [81][82][83][84][85][86] and hepatic caffeine metabolism now important to endothelial death and interference of the endothelial NO synthase Figure 3) in the plasma and secondary caffeine saturation of cell membranes. Caffeine can be converted to theophylline in cells but beneficial theophylline effects may be sensitive to toxic elevated caffeine levels in cells.…”