A Tailored Approach to the Treatment of a Patient with a Severe Dynamic Manifestation of Rosacea: A Case Report

Abstract

Rosacea is a chronic inflammatory disease that can manifest as a spectrum of symptoms including erythema, inflammatory lesions, edema, and telangiectasia. Treatment decisions need to be adapted to reflect the nature and severity of the different symptoms present. In this report, we discuss the case of a female patient diagnosed with severe, inflamed papulopustular rosacea (PPR) presenting with a large number of inflammatory lesions and severe background erythema. This patient responded well to a treatment regimen consisting of a short course of antibiotics in combination with a corticosteroid, followed by monotherapy with isotretinoin to reduce the inflammation. Brimonidine gel, used as needed, was then added to isotretinoin to target the remaining background erythema. This case of severe PPR required a combinatorial treatment regimen to effectively target all symptoms present. The patient continued to apply topical metronidazole throughout the different treatment regimens prescribed over the course of almost 1 year. Use of topical metronidazole helped to repair and protect the skin barrier, which minimized the occurrence of dermatological adverse events when topical treatments were used. We conclude that in patients with severe disease and an important inflammatory component, a rapid response can be obtained with a multimodal, tailored approach that also includes treatment to repair and protect the skin barrier.

Single-Exciton Gain and Stimulated Emission Across the Infrared Telecom Band from Robust Heavily Doped PbS Colloidal Quantum Dots

“…We calculated the stimulated emission occupancy threshold <N>thr by fitting the integrated PL spectra (see Supplementary Section 12) from the power dependent S-curves of all the samples. In Figure 3 10 To our knowledge, this is the first report of CQD ASE in the infrared characterized by ASE saturation and narrow linewidth, essential features of ASE that had remained elusive hitherto 19,36 . The stimulated emission threshold occupancy is summarized in Figure 3g.…”

“…The 8-fold degeneracy of PbS(e) CQDs, however, has hindered the demonstration of low-threshold optical gain and ASE, at room temperature, in the infrared across the telecommunications wavelength band. 19,20 We posited that a CQD film, robustly n-doped in the heavy doping regime, can address this challenge by utilizing the doping electrons present in the first excited state of the CQDs (conduction band) to reach the population inversion condition at reduced pumping fluence.…”

Dry‐Deposited Transparent Carbon Nanotube Film as Front Electrode in Colloidal Quantum Dot Solar Cells

“…[50] The multiple-exciton generation in CQD may be another promising route to further increaset he photovoltaic efficiency and circumvent the Shockley-Queisser limitation for single-bandgap-based solar cells. [8,[51][52][53][54][55][56][57] Continuing progress in the fundamental physical chemistry and device physics of each platform will be mutuallyb eneficial and bring many insights that apply to each platform.…”

Tuning Hole and Electron Transfer from Photoexcited CdSe Quantum Dots to Phenol Derivatives: Effect of Electron‐Donating and ‐Withdrawing Moieties

“…[9][10][11][12][13] Multiple excitong eneration (MEG) is ap rocess by which an adsorbedp hoton can generate more than one exciton, if the photon energy is more than twice the band gap of the quantumd ot (QD). [14][15][16][17][18][19][20] However,t he low efficiency of QDSCsi sp resumed to be observed due to ultrafast exciton-exciton annihilation. [21][22][23] It has been realized that it is very important to dissociatet he excitons before they go for annihilation.E xtraction of charge carriers can take place through electrono rh ole transfer from photoexcited QDs to as uitable molecular adsorbate or another semiconductor,b yw hich ultrafaste xciton-exciton annihilation can be reduced drastically.S everal literature reports are available in whiche xcitond issociation hasb een demonstrated through charget ransfer (CT) in different QD/molecule composite [24][25][26][27][28][29][30] and QD/semiconductor nanoparticle (TiO 2 ) [31][32][33] systems.…”