A Tailored Smoking, Alcohol, and Depression Intervention for Head and Neck Cancer Patients

Duffy, Sonia A.; Ronis, David L.; Valenstein, Marcia; Lambert, Monique; Fowler, Karen E.; Gregory, Lynn; Bishop, Carol; Myers, Larry L.; Blow, Frederic C.; Terrell, Jeffrey E.

doi:10.1158/1055-9965.epi-05-0880

Cited by 187 publications

(256 citation statements)

References 23 publications

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“…Given that at least one‐third of people with HNC continue to smoke and 16% continue to drink hazardously57 after receiving the primary HNC diagnosis, this is an important question to address. Few studies in the literature have examined patterns of smoking and alcohol drinking after diagnosis, but there is some evidence to suggest benefits of smoking cessation in terms of response to radiation therapy and reduced risk of second primary tumours 58.…”

Section: Discussionmentioning

confidence: 99%

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

Beynon

Lang

Schimansky

et al. 2018

Intl Journal of Cancer

134

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Tobacco smoking and alcohol consumption are well‐established risk factors for head and neck cancer. The prognostic role of smoking and alcohol intake at diagnosis have been less well studied. We analysed 1,393 people prospectively enrolled into the Head and Neck 5000 study (oral cavity cancer, n=403; oropharyngeal cancer, n=660; laryngeal cancer, n=330) and followed up for a median of 3.5 years. The primary outcome was all‐cause mortality. We used Cox proportional hazard models to derive minimally adjusted (age and gender) and fully adjusted (age, gender, ethnicity, stage, comorbidity, body mass index, HPV status, treatment, education, deprivation index, income, marital status, and either smoking or alcohol use) mortality hazard ratios (HR) for the effects of smoking status and alcohol intake at diagnosis. Models were stratified by cancer site, stage and HPV status. The fully‐adjusted HR for current versus never‐smokers was 1.7 overall (95% confidence interval [CI] 1.1, 2.6). In stratified analyses, associations of smoking with mortality were observed for oropharyngeal and laryngeal cancers (fully adjusted HRs for current smokers: 1.8 (95% CI=0.9, 3.40 and 2.3 (95% CI=0.8, 6.4)). We found no evidence that people who drank hazardous to harmful amounts of alcohol at diagnosis had a higher mortality risk compared to non‐drinkers (HR=1.2 (95% CI=0.9, 1.6)). There was no strong evidence that HPV status or tumour stage modified the association of smoking with survival. Smoking status at the time of a head and neck cancer diagnosis influenced all‐cause mortality in models adjusted for important prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

Beynon

Lang

Schimansky

et al. 2018

Intl Journal of Cancer

134

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“…31,36 Of the studies that included counseling, the most common therapy was in-person CBT. One included study, Duffy (2006), conducted behavioral counseling via telephone. 38 Six studies included behavioral mood management.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…One included study, Duffy (2006), conducted behavioral counseling via telephone. 38 Six studies included behavioral mood management. 25,26,[36][37][38][39] Behavioral mood management ranged from one-time mood management counseling to intensive multisession CBT.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…38 Six studies included behavioral mood management. 25,26,[36][37][38][39] Behavioral mood management ranged from one-time mood management counseling to intensive multisession CBT. Of the studies that included antidepressants, four used bupropion, 33,34,38,40 and three tested sertraline, fluoxetine, or nortriptyline.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

“…25,26,[36][37][38][39] Behavioral mood management ranged from one-time mood management counseling to intensive multisession CBT. Of the studies that included antidepressants, four used bupropion, 33,34,38,40 and three tested sertraline, fluoxetine, or nortriptyline. 25,35,41 Of studies that included antidepressants, three used NRT patches as a cotreatment, 34,38,41 and one used NRT patches as first-line therapy before offering bupropion.…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

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Smoking Cessation Interventions for Patients with Depression: A Systematic Review and Meta-analysis

et al. 2011

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OBJECTIVES:We conducted a systematic literature review of smoking cessation interventions for patients with histories of depressive disorders or current significant depressive symptoms. We examined the comparative effectiveness of smoking cessation strategies on abstinence rates, differential effects of cessation strategies by depression status (i.e., history positive vs. current depression), and differential effects by gender. DATA SOURCES: Peer-reviewed literature in MEDLINE, Embase, PsycINFO, and Cochrane Library. STUDY ELIGIBILITY CRITERIA, PARTICIPANTS, AND INTERVENTIONS: Randomized controlled trials or secondary analysis of RCT data comparing two or more smoking cessation interventions or intervention to control, and reporting cessation outcomes in adults with depression. STUDY APPRAISAL AND SYNTHESIS METHODS: Two trained researchers screened articles for inclusion. When possible, we estimated pooled risk ratios with 95% confidence intervals by using a random effects model with the Mantel-Haenszel method. We synthesized other studies qualitatively. We classified each intervention as antidepressants, nicotine replacement therapy (NRT), brief smoking cessation counseling, smoking cessation behavioral counseling, or behavioral mood management. RESULTS: We identified 16 unique RCTs, of which, only three trials recruited participants with current depression. Meta-analysis demonstrated a small, positive effect of adding behavioral mood management (RR = 1.41, 95% CI 1.01-1.96). All included antidepressant trials showed small, positive effects, but risk ratio summary was not significant (RR = 1.31, 95% CI 0.73-2.34). Three NRT trials demonstrated small, positive effects on smoking cessation rates. We found insufficient evidence to examine gender and depression status moderator effects. LIMITATIONS: Few RCTs exist that test smoking cessation interventions among adults with depression. To make meaningful comparisons, we created broad intervention categories that contained heterogeneity. CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS:Few trials enrolled smokers with current depression. Most of data identified were from subgroup analyses of patients history-positive for depression. However, several promising interventions exist. Healthcare providers should consider encouraging their patients with significant depressive symptoms or depression histories to seek smoking cessation services that include NRT and behavioral mood management.

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Changes in Quality of Life Over 1 Year in Patients With Head and Neck Cancer

Ronis¹,

Duffy²,

Fowler³

et al. 2008

Arch Otolaryngol Head Neck Surg

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106

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A Tailored Smoking, Alcohol, and Depression Intervention for Head and Neck Cancer Patients

Cited by 187 publications

References 23 publications

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all‐cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer

Smoking Cessation Interventions for Patients with Depression: A Systematic Review and Meta-analysis

Changes in Quality of Life Over 1 Year in Patients With Head and Neck Cancer

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