A tale of osteoarthritis among older adults during the COVID-19 pandemic in Bangladesh: A repeated cross-sectional study

Mistry, Sabuj Kanti; Ali, Arm Mehrab; Yadav, Uday Narayan; Gupta, Rajat Das; Anwar, Afsana; Basu, Saurav; Huda, Md. Nazmul; Mitra, Dipak Kumar

doi:10.1371/journal.pone.0274838

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Interestingly, cartilage degeneration and disturbances in the immune microenvironment are the main features of OA, which is the most common joint disease. Although researchers have noted a common clinical presentation and some potential associations between COVID-19 and OA patients, further studies on the shared molecular pathways and therapeutic strategies between these two diseases are needed ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

et al. 2023

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BackgroundCorona Virus Disease 2019 (COVID-19) and Osteoarthritis (OA) are diseases that seriously affect the physical and mental health and life quality of patients, particularly elderly patients. However, the association between COVID-19 and osteoarthritis at the genetic level has not been investigated. This study is intended to analyze the pathogenesis shared by OA and COVID-19 and to identify drugs that could be used to treat SARS-CoV-2-infected OA patients.MethodsThe four datasets of OA and COVID-19 (GSE114007, GSE55235, GSE147507, and GSE17111) used for the analysis in this paper were obtained from the GEO database. Common genes of OA and COVID-19 were identified through Weighted Gene Co-Expression Network Analysis (WGCNA) and differential gene expression analysis. The least absolute shrinkage and selection operator (LASSO) algorithm was used to screen key genes, which were analyzed for expression patterns by single-cell analysis. Finally, drug prediction and molecular docking were carried out using the Drug Signatures Database (DSigDB) and AutoDockToolsResultsFirstly, WGCNA identified a total of 26 genes common between OA and COVID-19, and functional analysis of the common genes revealed the common pathological processes and molecular changes between OA and COVID-19 are mainly related to immune dysfunction. In addition, we screened 3 key genes, DDIT3, MAFF, and PNRC1, and uncovered that key genes are possibly involved in the pathogenesis of OA and COVID-19 through high expression in neutrophils. Finally, we established a regulatory network of common genes between OA and COVID-19, and the free energy of binding estimation was used to identify suitable medicines for the treatment of OA patients infected with SARS-CoV-2.ConclusionIn the present study, we succeeded in identifying 3 key genes, DDIT3, MAFF, and PNRC1, which are possibly involved in the development of both OA and COVID-19 and have high diagnostic value for OA and COVID-19. In addition, niclosamide, ciclopirox, and ticlopidine were found to be potentially useful for the treatment of OA patients infected with SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

et al. 2023

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“…To specifically reduce potential feelings of helplessness, especially in cases where the osteoarthritis symptoms are possibly exacerbated by exposure to COVID-19 disease and long COVID infections [42][43][44][45], education directed towards fostering a clear understanding of their osteoarthritis condition and its potential both for worsening as well as for mitigation over time, especially among those adults with multiple morbidities, and breaking down what is needed to foster favourable outcomes into small doable steps is recommended. The provision of personalized levels of information and that is developed in conjunction with input from the older adult in question, as well as in consideration of their health literacy level, and degree of social support can also help to foster, rather than impede intervention adherence, while building a sense of control and a strong commitment to do all that is possible to minimize any further joint attrition or be placed at risk for a COVID infection.…”

Section: Resultsmentioning

confidence: 99%

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

Marks

2022

JARH

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Background Osteoarthritis, the most common joint disease and one affecting a large number of older adults is not always amenable to the use of passive interventions such as surgery or pharmacologic interventions, but even then, to maximize any desirable intervention approaches, a trustworthy and supportive partnership with the sufferer is strongly indicated. Complicating this process are emerging equity and persistent health literacy issues, as well as post COVID-19 service associated ramifications and persistent disease risks. Aim This mini review was designed to examine what current data reveal as regards the presentation of osteoarthritis and its pathology among the older adult as of the current post COVID-19 pandemic period in 2022, and how health literacy and equity issues are likely implicated in some degree with the disease presentation and its outcomes and will be likely to continue, unless remediated. Methods Peer reviewed published articles on this topic were sought from multiple data bases using the key words- osteoarthritis, health equity, health literacy, prevention, and intervention. Results As in prior years, osteoarthritis continues to induce considerable physical disability and consistently impedes the attainment of a high life quality for many older adults. Although not studied to any degree, attention to health equity and literacy issues appear to pose additional osteoarthritis intervention challenges, especially among the long COVID affected older adults and those with low income and educational levels. Conclusions Many behaviourally oriented and necessary osteoarthritis management approaches and interventions may fail to reduce the functional disability and pain experienced by older people with any form of osteoarthritis to any meaningful degree if a) the provider does not tailor their recommendations in light of possible prevailing health literacy, economic, and educational challenges; b) the patient does not understand how their health behaviours impact joint disease as well as COVID-19 risk status, and are not empowered to undertake these.

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“…[50][51][52] In short, unlike medications, which do not currently reverse the disease process, and may not be indicated for all older adults, along with surgery, a significant proportion of those older adults who wish to continue live independently in the community rather than the nursing home and who may suffer many challenges due to their osteoarthritis may yet tend to be better off in response to efforts to optimize joint biomechanics and life quality and self-efficacy than not. In the future, in addition to novel forms of intervention, there may also be a more well defined and key role for specific nutrient or dietary supplementation interventions 11,53 as well as phenotype specific intervention recommendations 54 that should be studied more intently.…”

Section: Possible Community Based Intervention Approachesmentioning

confidence: 99%

Untitled

2022

IPMRJ

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Background: Osteoarthritis, a highly common, disabling joint disease affecting a large number of older adults is presently incurable, and not always amenable to surgery or pharmacologic interventions.Purpose: Further complicated by multiple past and ongoing COVID-19 pandemic issues and disease consequences, the purpose was to examine what current data reveal as to the prevailing epidemiological features of osteoarthritis and its pathology. Another was to review the utility of some non-pharmacological and non-operative treatment strategies that have been advocated for alleviating the pain and disability of this disease in later life.Methods: Building on a 35 year prior review conducted in 2015, this current review was conducted to identify relevant literature published on this topic over the last 5 years, particularly since COVID-19 onset in 2019. Key words included osteoarthritis, COVID-19, prevention, and intervention. Results:As in prior years, osteoarthritis continues to induce considerable physical disability and consistently impedes the attainment of a high life quality for many older adults. Although not studied to any degree, COVID-19 factors may be expected to render further challenges that compound the disease presentation and its mitigation over time, especially among the long COVID affected older adult. In the face of closures, limited resources, and complex disease presentations, it does appear a variety of non-operative and non-pharmacologic approaches may yet influence the disease process and functional outcomes more positively than not with low safety risks. They may help the older adult more effectively even if surgery is indicated and multiple medications are yet required. Conclusion:The application of one or more carefully designed conservative interventions is likely to reduce the functional disability and pain experienced by older people with any form of osteoarthritis, regardless of whether surgical and or pharmacologic strategies are indicated.

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A tale of osteoarthritis among older adults during the COVID-19 pandemic in Bangladesh: A repeated cross-sectional study

Cited by 11 publications

References 22 publications

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

Identification of 3 key genes as novel diagnostic and therapeutic targets for OA and COVID-19

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

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