A Targeted and Adjuvanted Nanocarrier Lowers the Effective Dose of Liposomal Amphotericin B and Enhances Adaptive Immunity in Murine Cutaneous Leishmaniasis

Daftarian, Pirouz; Stone, Geoffrey W.; Kovalski, Letícia; Kumar, Manoj; Vosoughi, Aram; Urbieta, Maitee; Blackwelder, Patricia; Dikici, Emre; Serafini, Paolo; Duffort, Stéphanie; Boodoo, Richard; Rodríguez-Cortés, Alhelí; Lemmon, Vance; Deo, Sapna K.; Alberola, Jordi; Pérez, Víctor L.; Daunert, Sylvia; Ager, Arba L.

doi:10.1093/infdis/jit378

Cited by 51 publications

(41 citation statements)

References 28 publications

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“…These studies demonstrated that G5 PPI-mannose conjugate is a low toxic AmB formulation, providing prolonged release of carried drug. AmB was also the object of interest for Daftarian et al [79]. They prepared G5 PAMAM bound to a targeting peptide-Pan-DR-binding epitope.…”

Section: Dendrimers In Fighting Off the Parasitic/protozoa Infectionmentioning

confidence: 99%

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Mlynarczyk¹,

Kocki²,

Gośliński³

2017

Nanostructured Materials - Fabrication to Applications

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Dendrimers represent a distinct class of polymers-highly branched and uniform, with a relatively small size when compared to their mass. They are composed of the core, from which branched polymeric dendrons diverge and they are end-capped with selected terminal groups. Recently, dendrimers have attracted considerable attention from medicinal chemists, mostly due to their well-defined and easy-to-modify structure. This chapter aims to compile dendrimer applications and activities especially for prevention and fighting off infections caused by bacteria and fungi, viruses, and parasites/protozoa. Our goal in this review is to discuss selected modifications of dendrimers of potential value for pharmaceutical chemistry.

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Section: Dendrimers In Fighting Off the Parasitic/protozoa Infectionmentioning

confidence: 99%

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Mlynarczyk¹,

Kocki²,

Gośliński³

2017

Nanostructured Materials - Fabrication to Applications

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“…Córdoba y colaboradores (74) demostraron el potencial de glicodendrímeros para estimular DC y activar el sistema inmune. Se ha informado también que dendrímeros derivatizados (o sea, modificados químicamente para producir un compuesto con nuevas propiedades) con PADRE (por la sigla en inglés de pan HLA DR-binding epitope) tienen la capacidad de aumentar la eficacia de la anfotericina B liposomal y su orientación hacia las células presentadoras de antígeno, activando la respuesta inmune adaptativa como consecuencia de la activación de linfocitos T, con lo que se logra reducir la carga parasitaria en leishmaniasis cutánea murina (75).…”

Section: Dendrímerosunclassified

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Gómez-Gallego

Urcuqui-Inchima

Hernández

2016

iatreia

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RESUMENLas nanopartículas (NP) son estructuras con tamaño en la escala nanométrica (1 x 10 -9 m). Por sus características, en los últimos años ha crecido su potencial para usarlas en los campos biotecnológico y biomédico en una amplia gama de aplicaciones, tales como el diagnóstico, la terapia y la medicina regenerativa.El sistema inmunológico es el responsable de la defensa del cuerpo ante organismos patógenos y otros agentes extraños, como las NP, que pueden ser reconocidas por dicho sistema, interactuar con él y modular su función induciendo efectos inmunosupresores o inmunoestimuladores. Las primeras se podrían utilizar como agentes terapéuticos antinflamatorios o para tratar las enfermedades autoinmunes, y las que activan el sistema inmune, como adyuvantes en vacunación o potenciadores de la respuesta inmune en cáncer y otras enfermedades humanas. Sin embargo, su uso en nanomedicina debe estar sujeto a ensayos previos que determinen su efecto en la respuesta inmune antes de aplicarlas a los sistemas biológicos. Por esta razón es importante conocer su composición, tamaño y características superficiales, entre otras propiedades fisicoquímicas, directamente implicadas en los efectos sobre el sistema inmune. Se presenta una visión general de la relación entre las propiedades fisicoquímicas de las NP candidatas para ser usadas en los campos biomédico y biotecnológico y su actividad inmunomoduladora. PALABRAS CLAVEInmunomodulación; Nanomedicina; Nanopartículas SUMMARYImmunomodulating effect of nanoparticles used in nanomedicine Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10 -9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in

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“…In addition to siRNA delivery, the ideal nanoparticles should provide sustained release of antimicrobials to inhibit the proliferation of pathogens, while simultaneously accelerating cell migration. Importantly, nanoparticles such as dendrimers were shown to be an effective way of delivering Ambisome, an antifungal drug, for treating cutaneous Leishmaniasis in a mouse model that included reduced drug toxicity (Daftarian et al, 2013). Nitric oxide-loaded nanoparticles have shown promising antimicrobial activity in a murine wound model (Krausz et al, 2015).…”

Section: Microtubule Network and Directional Movementmentioning

confidence: 99%

Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing

Jozic

Daunert

Tomic‐Canic

et al. 2015

Journal of Investigative Dermatology

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Complex spatiotemporal interaction of Rho GTPases with microtubules (MTs) and MT-associated proteins drives directed cellular migration. In this issue, Charafeddine et al. describe a role for a novel MT-severing enzyme, fidgetin-like 2 (FL2), in directional migration of keratinocytes and fibroblasts. FL2 normally localizes to the leading edge of the cell cortex where it shears MTs, thus dictating the size and distribution of focal adhesions by regulating cytoskeletal remodeling. Small interfering RNA (siRNA)-directed knockdown of FL2 increases cell migration and focal adhesion area in vitro through possible interaction with Rho GTPases. Efficient FL2 knockdown in murine wounds was achieved using nanoparticles as a siRNA delivery vehicle, and this resulted in enhanced wound closure in vivo. Effective siRNA nanoparticle targeting of MT-severing enzymes offers promise of controlled and targeted delivery that may maximize therapeutic success for patients with burn wounds and chronic wound disorders.

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A Targeted and Adjuvanted Nanocarrier Lowers the Effective Dose of Liposomal Amphotericin B and Enhances Adaptive Immunity in Murine Cutaneous Leishmaniasis

Cited by 51 publications

References 28 publications

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing

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