A technique for investigating changes in the surface roughness of tablets during film coating

Prater, D.A.; Meakin, B. J.; Rowe, R.C.; Wilde, J.S.

doi:10.1111/j.2042-7158.1981.tb13896.x

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased spray rate reduced roughness but increased coating level produced the opposite effect. The latter was also observed in other studies on film coating of tablets (23). However, roughness was excluded in the optimization studies because an 'optimum' roughness value was difficult to define.…”

Section: Screeningmentioning

confidence: 49%

Optimization of Process Parameters for a Quasi-Continuous Tablet Coating System Using Design of Experiments

2010

View full text Add to dashboard Cite

Abstract. The aim of this study was to identify and optimize the critical process parameters of the newly developed Supercell quasi-continuous coater for optimal tablet coat quality. Design of experiments, aided by multivariate analysis techniques, was used to quantify the effects of various coating process conditions and their interactions on the quality of film-coated tablets. The process parameters varied included batch size, inlet temperature, atomizing pressure, plenum pressure, spray rate and coating level. An initial screening stage was carried out using a 2 6−1(IV) fractional factorial design. Following these preliminary experiments, optimization study was carried out using the Box-Behnken design. Main response variables measured included drug-loading efficiency, coat thickness variation, and the extent of tablet damage. Apparent optimum conditions were determined by using response surface plots. The process parameters exerted various effects on the different response variables. Hence, trade-offs between individual optima were necessary to obtain the best compromised set of conditions. The adequacy of the optimized process conditions in meeting the combined goals for all responses was indicated by the composite desirability value. By using response surface methodology and optimization, coating conditions which produced coated tablets of high drug-loading efficiency, low incidences of tablet damage and low coat thickness variation were defined. Optimal conditions were found to vary over a large spectrum when different responses were considered. Changes in processing parameters across the design space did not result in drastic changes to coat quality, thereby demonstrating robustness in the Supercell coating process.

show abstract

Section: Screeningmentioning

confidence: 49%

Optimization of Process Parameters for a Quasi-Continuous Tablet Coating System Using Design of Experiments

2010

View full text Add to dashboard Cite

show abstract

“…The friction coefficient slightly increased as the coating weight gain increased. One explanation is that the surface roughness of the tablets increased as the coating weight gain increased, as observed in other studies on tablet film coatings [24,25] . The friction coefficient increased as the spray rate increased because the droplet sizes increase as the spray rate increases, and the drops cannot fully dry in a short time, leading to high surface roughness and a large friction coefficient [26] .…”

Section: Friction Coefficientmentioning

confidence: 52%

Optimization of tracer coating parameters and their effects on the mechanical properties and quality of food-grade tracers for grain traceability

Liang¹,

Zhang²,

Chen³

et al. 2019

International Journal of Agricultural and Biological Engineering

View full text Add to dashboard Cite

The purpose of this study was to optimize the coating process of food-grade tracers to manufacture tracers with good physical, mechanical and practical properties and an excellent appearance. The effects of the coating weight gain (1.00%-5.00%), coating solution spray rate (1.50-7.50 g/min) and tablet bed temperature (30°C-40°C) on the coating appearance quality, moisture absorption rate, friction coefficient, peak shear force, breaking rate, barcode recognition rate, transport wear rate and transport recognition rate were analysed using a Box-Behnken design (BBD) of response surface methodology (RSM). The experimental data were fitted to quadratic polynomial models by multiple regression analysis. The mathematical models of the barcode recognition rate, transport wear rate and transport recognition rate exhibited no statistically significant difference in these data. The optimum coating parameters were as follows: a 5.00% coating weight gain, spray rate of 5.47 g/min and tablet bed temperature of 35.42°C. Under the optimized conditions, the tracers had a good appearance (coating appearance quality), moisture resistance (moisture absorption rate), and frictional (friction coefficient), compression (peak shear force), and impact characteristics (breaking rate).

show abstract

Entwicklung von umhüllten Tabletten

Sticker

2003

Arzneiformen-Entwicklung

View full text Add to dashboard Cite

A technique for investigating changes in the surface roughness of tablets during film coating

Cited by 4 publications

References 2 publications

Optimization of Process Parameters for a Quasi-Continuous Tablet Coating System Using Design of Experiments

Optimization of Process Parameters for a Quasi-Continuous Tablet Coating System Using Design of Experiments

Optimization of tracer coating parameters and their effects on the mechanical properties and quality of food-grade tracers for grain traceability

Entwicklung von umhüllten Tabletten

Contact Info

Product

Resources

About