Mucormycosis is a rapidly progressing and invasive form of fungal infection involving the nose and paranasal sinuses of head and neck region with high mortality and morbidity. Compromised immunological conditions like uncontrolled diabetics mellitus, Leukaemia, prolonged use of steroids are the most common predisposing factors for this disease. Aggressive surgical debridement including resection of involved maxillofacial structures like orbit, maxilla and/or nose is the commonly used treatment protocol in such conditions. Rehabilitation of such large maxillofacial defects is a Prosthodontic challenge and many problems are encountered in rehabilitation like lack of retention due to dislodging forces exerted by scarred post surgical soft tissues, lack of bony base, lost structures of the posterior palatal seal area, multiple defect sites and compromised medical status due to comorbidities that also affects healing rate of the defect. This clinical report describes prosthetic rehabilitation of a patient with residual maxillary and orbital defects secondary to surgical management of sinoorbital mucormycosis with a combination prosthesis comprising of orbital and obturator using an innovative method of achieving retention between the two, thereby providing complete functional and esthetic rehabilitation of the patient.