A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery

Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario

doi:10.1016/j.jddst.2024.105419

Cited by 4 publications

References 86 publications

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Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Yingngam,

Makewilai,

Chaisawat

et al. 2024

Medical Applications for Biocompatible Surfaces and Coatings

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The encapsulation of active pharmaceutical ingredients (APIs) in microbeads is an essential step in drug delivery; however, it is also inherently associated with the need to control particle size and drug release profiles. Nevertheless, most conventional methods of microencapsulation fail to provide consistent results. A new method called vibration-assisted microbead coating is a novel unified technique utilizing mechanical vibrations to enable the controlled, uniform coating of microbeads on APIs. This chapter discusses the technology of vibration-assisted encapsulation performed by the authors through microbead formation and the physical activity of coating APIs. This chapter focuses on achieving uniform control of the final coated surface of the API, microbead shape, size, and loading through vibration parameters. Additionally, this chapter discusses the biocompatibility and stability of the final coated surface. This new means of encapsulation has high potential for drug delivery. This method reduces most of the traditional challenges of encapsulation, if not eliminates them, and is more reliable. Based on the abovementioned findings, the authors propose the following main areas for their further work: optimisation of vibration parameters for various APIs, research into the long-term stability of the loading–release profile, and possible use of the technique in targeted drug delivery.

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Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Yingngam,

Makewilai,

Chaisawat

et al. 2024

Medical Applications for Biocompatible Surfaces and Coatings

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QbD-based co-loading of paclitaxel and imatinib mesylate by protamine-coated PLGA nanoparticles effective on breast cancer cells

Laxane,

Yadav

2024

Nanomedicine

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Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy

Jiang,

Wang

et al. 2024

IJMS

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RNA is a promising nucleic acid-based biomolecule for various treatments because of its high efficacy, low toxicity, and the tremendous availability of targeting sequences. Nevertheless, RNA shows instability and has a short half-life in physiological environments such as the bloodstream in the presence of RNAase. Therefore, developing reliable delivery strategies is important for targeting disease sites and maximizing the therapeutic effect of RNA drugs, particularly in the field of immunotherapy. In this mini-review, we highlight two major approaches: (1) delivery vehicles and (2) chemical modifications. Recent advances in delivery vehicles employ nanotechnologies such as lipid-based nanoparticles, viral vectors, and inorganic nanocarriers to precisely target specific cell types to facilitate RNA cellular entry. On the other hand, chemical modification utilizes the alteration of RNA structures via the addition of covalent bonds such as N-acetylgalactosamine or antibodies (antibody–oligonucleotide conjugates) to target specific receptors of cells. The pros and cons of these technologies are enlisted in this review. We aim to review nucleic acid drugs, their delivery systems, targeting strategies, and related chemical modifications. Finally, we express our perspective on the potential combination of RNA-based click chemistry with adoptive cell therapy (e.g., B cells or T cells) to address the issues of short duration and short half-life associated with antibody–oligonucleotide conjugate drugs.

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A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery

Cited by 4 publications

References 86 publications

Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

Vibration-assisted Microbead Production: A New Frontier for Biocompatible Surfaces

QbD-based co-loading of paclitaxel and imatinib mesylate by protamine-coated PLGA nanoparticles effective on breast cancer cells

Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy

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