The ubiquity of the global Internet, social networks, online marketplaces, and other types of services has fostered the development of information and communication technologies (ICTs), including in the healthcare industry. One of the successful and promising uses of ICTs is telemedicine, the interest in which increased during the COVID-19 pandemic. The authors developed their own version of telemedicine questionnaire screening of adult health. The created telemedical questionnaire screening system includes a methodology of selection and ranking of questions, which allows determining the degree of existing health risk in specific profiles: cardiology, gastroenterology, pulmonology, endocrinology and oncology. Due to the presence of artificial intelligence, the system developed by us, is able to form a personalized final medical conclusion and recommendations for a healthy lifestyle. The advantages of the program include a personalized approach, no binding to place and time, flexibility of decisive rules adequate to the expert physician’s opinion, proprietary methodology of selection and ranking of clinical symptoms taking into account their degree of expression and validity, formation of a pathology profile rather than a nosological unit, which ultimately increases the information value of screening and covers all major body systems. Convenience and clarity of the results and conclusions contribute to the formation of adherence to a healthy lifestyle, refusal from bad habits, and increase the awareness of the program users in the issues of prevention and diagnostics of non-infectious diseases. The development will make it possible to reduce the time spent on outpatient appointments by 20% when using the program in primary health care facilities.