A teleostean angiotensinogen from Oplegnathus fasciatus responses to immune and injury challenges

Umasuthan, Navaneethaiyer; Whang, Ilson; Revathy, Kasthuri Saranya; Oh, Myung‐Joo; Jung, Sung‐Ju; Choi, Cheol Young; Lee, Jehee; Noh, Jae Koo

doi:10.1016/j.fsi.2012.01.019

Cited by 6 publications

(2 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…This network is believed to contribute to the early physiological adaptations in response to V. alginolyticus infection, ultimately enhancing the fish's resistance to the pathogen. While limited research has focused on the functional role of HABP2, AGT and Serpin A3‐2 in fish, they are known for their capacity to maintain structural and connective tissues (de Mezer et al., 2023; Nickerson et al., 2006; Umasuthan et al., 2012). Conversely, Fg plays a pivotal role in blood clotting, serving as the scaffold for blood clots and facilitates tissue healing at injury site (Freire et al., 2020; Li, Liu, et al., 2022; Tavares‐Dias & Oliveira, 2009; Yang et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

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Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Abu Aziz,

Christianus,

Wan Solahudin

et al. 2024

Journal of Fish Diseases

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Vibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non‐haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio‐resistant and Vibrio‐susceptible grouper. Samples were analysed using high‐throughput LC‐MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up‐regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease‐resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.

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Section: Discussionmentioning

confidence: 99%