“…Although plants are more tolerant to defects in CAF-1 function than mammals, alteration in the H3.1/H3.3 balance seems to be highly deleterious for plant development, as revealed by the pleiotropic phenotype of fas1 , fas2 , and msi1 mutants, encoding each of the three CAF-1 subunits (Kaya et al, 2001; Hennig et al, 2003; Ramirez-Parra and Gutierrez, 2007a). Thus, fas1 mutants show increased homologous recombination, limited TE silencing, telomere shortening, and loss of 45S rDNA repeats (Endo et al, 2006; Kirik et al, 2006; Ono et al, 2006; Schonrock et al, 2006; Mozgova et al, 2010; Jaske et al, 2013). Likewise, asf1a, b double mutants exhibit a S-phase delay and up-regulation of checkpoint genes, such as ATM , ATR , and PARP1 (Zhu et al, 2011).…”