A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing

Han, Xiaopeng; Zhang, Yu; Zhang, Yundong; Song, Qinghao; Hasi, Wuliji; Lin, Siyu; Wang, Fan

doi:10.1016/j.aca.2024.342820

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2024.342820

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A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing

Xiaopeng Han,

Yu Zhang,

Yundong Zhang

et al.

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Single-Base Resolution Photonic-Integrated Chips via Hybrid Dielectric–Metal Nanocavities for Ultrasensitive Multichannel Biosensing

Du,

Zhang,

Xie

et al. 2024

ACS Photonics

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The development of highly precise and rapid biological photonic-integrated chips with single-base resolution for target gene detection holds immense potential to revolutionize genetic diagnostics and nonlinear optical devices. Our recent study presents the design of a single-base resolution photonic-integrated chip (SRPIC) with multichannel biosensing capabilities, enabling discrimination between gene segment sequences differing by a single nucleotide at sample concentrations below 1 fM. Through the utilization of hybrid dielectric−metal nanocavity arrays, the SRPIC established an efficient biosensing platform by motivating light-biological matter coupling behavior. This accomplishment represents an extraordinary 10 4 -fold increase in the limit of detection (LOD) compared with the CRISPR-HOLMES technique, exhibiting nearly impeccable precision during clinical testing. Our research highlights the potential of SRPIC as a powerful tool for the development of high-performance photonic-integrated chips capable of achieving multichannel single-base resolution biosensing, with each channel representing the detection of a single virus.

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Single-Base Resolution Photonic-Integrated Chips via Hybrid Dielectric–Metal Nanocavities for Ultrasensitive Multichannel Biosensing

Du,

Zhang,

Xie

et al. 2024

ACS Photonics

View full text Add to dashboard Cite

show abstract

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A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing

Cited by 1 publication

References 54 publications

Single-Base Resolution Photonic-Integrated Chips via Hybrid Dielectric–Metal Nanocavities for Ultrasensitive Multichannel Biosensing

Single-Base Resolution Photonic-Integrated Chips via Hybrid Dielectric–Metal Nanocavities for Ultrasensitive Multichannel Biosensing

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