The advantageous applications of magnetic bistable microwires have emerged during long-lasting research. They have a wide range of applications in the scientific sphere or technical practice. They can be used for various applications, including magnetic memories, biomedicine, and sensors. This manuscript is focused on the last-mentioned application of microwires—sensors—discussing various digital signal processing techniques used in practical applications. Thanks to the highly sensitive properties of microwires and their two stable states of magnetization, it is possible to perform precise measurements with less demanding digital processing. The manuscript presents four practical signal-processing methods of microwire response using three different experiments. These experiments are focused on detecting the signal in a simple environment without an external magnetic background, measuring with the external background of a ferromagnetic core, and measuring in harsh conditions with a strong magnetic background. The experiments aim to propose the best method under various conditions, emphasizing the quality and signal processing speed of the microwire signal.