The European land carbon uptake has been heavily impacted by several recent severe droughts, yet quantitative estimates of carbon uptake anomalies are uncertain. Atmospheric CO 2 inverse models (AIMs) provide observation-based estimates of the large-scale carbon flux dynamics, but how well they capture drought impacts on the terrestrial carbon uptake is poorly known. Here we assessed the capacity of state-of-the-art AIMs in monitoring drought impacts on the European carbon uptake over 2001-2015 using observations of environmental variability and vegetation function and made comparisons with bottom-up estimates of carbon uptake anomalies. We found that global inversions with only limited surface CO 2 observations give divergent estimates of drought impacts. Regional inversions assimilating denser CO 2 observations over Europe demonstrated some improved consistency, with all inversions capturing a reduction in carbon uptake during the 2012 drought. However, they failed to capture the reduction caused by the 2015 drought. Finally, we found that a set of inversions that assimilated satellite XCO 2 or assimilated environmental variables plus surface CO 2 observations better captured carbon uptake anomalies induced by both the 2012 and 2015 droughts. In addition, the recent Orbiting Carbon Observatory-2 XCO 2 inversions showed good potential in capturing drought impacts, with better performances for larger-scale droughts like the 2018 drought. These results suggest that surface CO 2 observations may still be too sparse to fully capture the impact of drought on the carbon cycle at subcontinental scales over Europe, and satellite XCO 2 and ancillary environmental data can be used to improve observational constraints in atmospheric inversion systems.Plain Language Summary Atmospheric CO 2 inverse models (AIMs) are useful tools for quantifying the response of large-scale carbon uptake to climate extremes, but their capacity for monitoring drought impacts, particularly at regional scales, is not fully explored. In this study, we assessed the capacity of state-of-the-art AIMs for monitoring drought impacts on the European land carbon uptake over 2001-2015 using a large array of observational and model data sets. We found: (a) global inversions with only limited surface CO 2 observations face a great challenge in monitoring drought impacts on the European carbon uptake; (b) Regional inversions assimilated denser CO 2 observations over Europe, for the EUROCOM project, demonstrated some improved consistency but are still deficient, showing divergent estimates in interannual variability of carbon uptake for most years; and (c) A set of inversion systems that assimilated satellite XCO 2 or assimilated environmental variables plus surface CO 2 observations better captured annual and seasonal HE ET AL.