In this paper, a Mobility Assistive System (NOVA-MAS) and a model-driven development approach are proposed to support the acquisition and analysis of data, infrastructures control, and dissemination of information along public roads. A literature review showed that the work related to mobility assistance of pedestrians in wheelchairs has a gap in ensuring their safety on road. The problem is that pedestrians in wheelchairs and scooters often do not enjoy adequate and safe lanes for their circulation on public roads, having to travel sometimes side by side with vehicles and cars moving at high speed. With NOVA-MAS, city infrastructures can obtain information regarding the environment and provide it to their users/vehicles, increasing road safety in an inclusive way, contributing to the decrease of the accidents of pedestrians in wheelchairs. NOVA-MAS not only supports information dissemination, but also data acquisition from sensors and infrastructures control, such as traffic light signs. For that, it proposed a development approach that supports the acquisition of data from the environment and its control while using a tool framework, named IOPT-Tools (Input-Output Place-Transition Tools). IOPT-Tools support controllers’ specification, validation, and implementation, with remote operation capabilities. The infrastructures’ controllers are specified through IOPT Petri net models, which are then simulated using computational tools and verified using state-space-based model-checking tools. In addition, an automatic code generator tool generates the C code, which supports the controllers’ implementation, avoiding manual codification errors. A set of prototypes were developed and tested to validate and conclude on the feasibility of the proposals.