A Terrylene–Anthraquinone Dyad as a Chromophore for Photothermal Therapy in the NIR-II Window

Wu, Ze-Hua; Peng, Min; Ji, Chendong; Kardasis, Panagiotis; Tzourtzouklis, Ioannis; Baumgarten, Martin; Wu, Hao; Basché, Thomas; Floudas, George; Yin, Meizhen; Müllen, Klaus

doi:10.1021/jacs.3c11314

Cited by 25 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Precise control over the heat generation is achieved by adjusting laser intensity, duration and photothermal agent concentration [8] . This laser‐triggered treatment exhibits significant selectivity and fewer side effects compared to conventional radiation and chemotherapy [9] . At present, organic molecular photothermal agents, recognized for their high photothermal conversion efficiency and easy structure modification, are widely applied in molecular agent‐based PTT, finding diverse applications in biology and medicine [10] .…”

Section: Methodsmentioning

confidence: 99%

A BRD4‐Targeting Photothermal Agent for Controlled Protein Degradation

Shi,

Li,

Pan

et al. 2024

Angew Chem Int Ed

View full text Add to dashboard Cite

BRD4 protein plays a pivotal role in cell cycle regulation and differentiation. Disrupting the activity of BRD4 has emerged as a promising strategy for inhibiting the growth and proliferation of cancer cells. Herein, we introduced a BRD4‐targeting photothermal agent for controlled protein degradation, aiming to enhance low‐temperature photothermal therapy (PTT) for cancer treatment. By incorporating a BRD4 protein inhibitor into a cyanine dye scaffold, the photothermal agent specifically bond to the bromodomain of BRD4. Upon low power density laser irradiation, the agent induced protein degradation, directly destroying the BRD4 structure and inhibiting its transcriptional regulatory function. This strategy not only prolonged the retention time of the photothermal agent in cancer cells but also confined the targeted protein degradation process solely to the tumor tissue, minimizing side effects on normal tissues through the aid of exogenous signals. This work established a simple and feasible platform for future PTT agent design in clinical cancer treatment.

show abstract

Section: Methodsmentioning

confidence: 99%

A BRD4‐Targeting Photothermal Agent for Controlled Protein Degradation

Shi,

Li,

Pan

et al. 2024

Angew Chem Int Ed

View full text Add to dashboard Cite

show abstract

“…Various chemical modification strategies have been developed to enhance the PCE of these dye molecules. For example, introducing electron donor/acceptor functional groups onto the dye molecule can enhance the ICT process, suppress radiative transitions, and promote non‐radiative transitions, thereby increasing heat generation (Wu, Peng, et al, 2023). Incorporating rotor structures into dye molecules can enhance energy dissipation and conversion into heat (Li et al, 2019).…”

Section: Mechanism Of the Enhanced Photothermal Performance Of Dye Ag...mentioning

confidence: 99%

Aggregation‐enhanced photothermal therapy of organic dyes

Yang,

Ji,

Yin

2024

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Photothermal therapy (PTT) represents a groundbreaking approach to targeted disease treatment by harnessing the conversion of light into heat. The efficacy of PTT heavily relies on the capabilities of photothermal agents (PTAs). Among PTAs, those based on organic dyes exhibit notable characteristics such as adjustable light absorption wavelengths, high extinction coefficients, and high compatibility in biological systems. However, a challenge associated with organic dye‐based PTAs lies in their efficiency in converting light into heat while maintaining stability. Manipulating dye aggregation is a key aspect in modulating non‐radiative decay pathways, aiming to augment heat generation. This review delves into various strategies aimed at improving photothermal performance through constructing aggregation. These strategies including protecting dyes from photodegradation, inhibiting non‐photothermal pathways, maintaining space within molecular aggregates, and introducing intermolecular photophysical processes. Overall, this review highlights the precision‐driven assembly of organic dyes as a promising frontier in enhancing PTT‐related applications.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools > In Vivo Nanodiagnostics and Imaging

show abstract

“…14 Instead, photothermal materials in the NIR-II window (1000–1200 nm) display higher biocompatibility because the NIR-II range is almost transparent to tissues. 15–18 In addition, because a strong photothermal effect can also burn the normal tissues and result in many side effects, mild-photothermal therapy (MPTT) has been developed and was demonstrated to be the safer therapeutic methodology. 19 Nevertheless, it is difficult for MPTT alone to completely inhibit the bacterial growth; its combination with other therapeutic strategies is necessary in order to achieve satisfying antibacterial outcomes.…”

Section: Introductionmentioning

confidence: 99%