A test for the determination of thevitamin C storage

Kajdi, Laslo; Light, Jacob; Kajdi, C. N.

doi:10.1016/s0022-3476(39)80029-4

Cited by 17 publications

(3 citation statements)

References 10 publications

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“…However, it seems unlikely that ascorbic acid in reduced form could be present after 20 minutes of boiling in contact with air, especially since none was detected in milk specimens in which turbidity did not interfere. (14) and others, that the response to a test dose is more significant than single plasma ascorbic acid determinations. The latter show much variation even in infants of presumably the same nutritional status.…”

Section: Resultsmentioning

confidence: 99%

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The Influence of Diet on the Ascorbic Acid Requirement of Premature Infants

Dann¹

1942

J. Clin. Invest.

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The purpose of this report is to present data, obtained on premature infants, demonstrating that one of the factors determining the need for ascorbic acid is the level of protein intake. It is proposed that this factor plays a role in the greater requirement of artificially fed babies, as compared to breast-fed infants, for supplements containing this vitamin.Long before actual data were available as to the daily total ascorbic acid requirement of the newborn infant, or as to the amount of the vitamin present in human and other milks, it was the common clinical observation that when scurvy occurred in infancy it was in the artificially fed baby. It was assumed that the protection of the breastfed infant against the disease could be attributed to the antiscorbutic activity of breast milk. This opinion was confirmed by experimental evidence, which has been well summarized in a recent review by Smith (1). The evidence includes the important findings of Selleg and King (2) who showed that the actual amount of ascorbic acid received by an infant ingesting an adequate volume of breast milk from a mother whose diet is adequate in this factor closely approaches the amount which other observers have determined to be the approximate daily requirement of the newborn infant. Determinations of blood plasma ascorbic acid levels by Braestrup (3), Mindlin (4, 5), Snelling (6) and others in babies of various ages, but particularly in the first weeks of life, reveal that these levels are on the average much lower in formula-fed than in breast-fed infants. Moreover, Mindlin (5) demonstrated a definite relationship between the plasma ascorbic acid level of the infant and the amount shown to be present in the mother's milk. However, Mindlin also found (4, 7) that even with supplements of 20 to 75 mgm. of ascorbic acid daily, formula-fed infants had lower levels, determined 16 hours after the last vitamin C dose, than did breast-fed infants receiving no supplements, and Braestrup (3) observed that daily dosages of 20 mgm. of ascorbic acid had a slow effect in raising the plasma levels in babies given boiled cow's milk. These observations are only partially explained on the assumption that the ascorbic acid requirement of the breast-fed and the formula-fed infant is the same, and that the former receives all or part of it in milk whereas the latter, whose feeding is prepared by heating in the presence of air, receives practically none. The supposition that the total daily requirement of infants receiving cow's milk is actually higher than that of infants receiving human milk is more completely consistent with the findings of the authors cited.The suggestion that the daily protein intake, which is usually at least twice as high with cow's milk formulas as with human milk, might play a role was made by Levine, Gordon, and Marples (8) as a result of observations on the amino acid metabolism of infants. They demonstrated the excretion of incompletely oxidized derivatives of phenylalanine and tyrosine in the urine of premature infants who...

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Section: Resultsmentioning

confidence: 99%

“…In these 4 infants the final dose was an intramuscular one of 100 mgm. ascorbic acid which was followed by a test similar to that of Kadji, Light and Kadji (14). The results are recorded in Table II.…”

Section: Subjects and Dietsmentioning

confidence: 99%

The Influence of Diet on the Ascorbic Acid Requirement of Premature Infants

Dann¹

1942

J. Clin. Invest.

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“…Several authors 160 have concluded that these methods are superior to those which depend on fasting levels of plasma. Several authors 160 have concluded that these methods are superior to those which depend on fasting levels of plasma.…”

Section: Pyridoxine (Vitamin B6)mentioning

confidence: 99%