Background
Regaining locomotor ability is a primary goal in stroke rehabilitation and is most commonly measured using changes in self-selected walking speed. However, walking speed cannot identify the mechanisms by which an individual recovers. Laboratory-based mechanistic measures such as exercise capacity, muscle activation, force production, and movement analysis variables may better explain neurologic recovery.
Objectives
The objectives of this systematic review are to examine changes in mechanistic gait outcomes and describe motor recovery as quantified by changes in laboratory-based mechanistic variables in rehabilitation trials.
Methods
Following a systematic literature search (in PubMed, Ovid, and CINAHL), we included rehabilitation trials with a statistically significant change in self-selected walking speed post-intervention that concurrently collected mechanistic variables. Methodological quality was assessed using the Cochrane Collaboration's tool. Walking speed changes, mechanistic variables, and intervention data were extracted.
Results
25 studies met the inclusion criteria and examined: cardiorespiratory function (n=5), muscle activation (n=5), force production (n=11), and movement analysis (n=10). Interventions included: aerobic training, functional electrical stimulation, multidimensional rehabilitation, robotics, sensory stimulation training, strength/resistance training, task-specific locomotor rehabilitation, and visually-guided training.
Conclusions
Following this review, no set of outcome measures to mechanistically explain changes observed in walking speed was identified. Nor is there a theoretical basis to drive the complicated selection of outcome measures, as many of these outcomes are not independent of walking speed. Since rehabilitation literature has yet to support a causal, mechanistic link for functional gains post stroke, a systematic, multi-modal approach to stroke rehabilitation will be necessary in doing so.