A tetranucleotide repeat polymorphism in the CYP19 gene and breast cancer susceptibility in a Greek population exposed and not exposed to pesticides

Dialyna, I. A.; Tzanakakis, George N.; Dolapsakis, George; Tsatsakis, Aristidis

doi:10.1016/j.toxlet.2004.01.024

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…A study on different ethnic groups (African-Americans, Japanese, Latinas, and non-Latina Whites) by Probst-Hensch et al [29] reported contradictory results and showed no consistent association of (TTTA)n repeat polymorphism with breast cancer risk. This was in line with other studies from the USA [30] and Greece [31]. These studies show that the tetranucleotide polymorphism occurs in different populations, and the repeat variants show association with breast cancer in some and not others.…”

Section: Short Tandem Repeat (Str) Polymorphismsupporting

confidence: 92%

“…A TCT insertion/deletion (ins/del) polymorphism occurs in the intron 4 of the CYP19A gene, approximately 50 bp upstream to the (TTTA)n repeat. A few studies have linked breast cancer to the trinucleotide TCT deletion [31,41]. In the British population, the TCT ins/del and a G-->T substitution in intron 4 were of rare occurrence (0.35 and 0.45, respectively), and both were in linkage disequilibrium with (TTTA)10 allele, which was reported to be linked to breast cancer susceptibility [41].…”

Section: Tct Insertion/deletion In Intronmentioning

confidence: 99%

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Genetic Polymorphisms in Aromatase (CYP19) Gene and Cancer

Warsy¹,

Al-Mukaynizi²,

Al-Daihan³

et al. 2017

Genetic Polymorphisms

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Estrogens play an important role in the development and progression of several types of cancers. The synthesis of estrogens occurs in almost all tissues of the body in addition to the gonads. The enzyme aromatase (CYP19A1) encoded by CYP19A1 gene is involved in the synthesis of estrogens. Genetic variations in CYP19A1 gene influence both the structure-function relationship of the enzyme and the rate of its synthesis. Extensive studies have reported different types of polymorphisms in the CYP19A1 gene and have shown that the polymorphisms, depending on their location in the gene, have different effects on the function and activity of the gene product. Association studies have been conducted and have led to the realization that interpopulation differences are widespread. Not only do polymorphic forms exert different effects on the development of different cancers, due possibly to the influence of other genetic variations, environmental, metabolic, and epigenetic factors, but also are important as they lead to the interindividual differences seen during treatment of the cancer state. This chapter covers important aspects of the aromatase function, the CYP19A1 gene structure, polymorphisms identified in the gene, different cancers and associated polymorphisms, and the role of the polymorphic forms in affecting the treatment strategies.

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Section: Short Tandem Repeat (Str) Polymorphismsupporting

confidence: 92%

Section: Tct Insertion/deletion In Intronmentioning

confidence: 99%

Genetic Polymorphisms in Aromatase (CYP19) Gene and Cancer

Warsy¹,

Al-Mukaynizi²,

Al-Daihan³

et al. 2017

Genetic Polymorphisms

View full text Add to dashboard Cite

show abstract

“…Changes in human CYP19 aromatase expression may then lead to a predisposition to cancer development. One study examined a polymorphism in the CYP19 gene in a Greek population and linked this polymorphism, the population exposure to pesticides, and the incidence of breast cancer [74]. This study did not find a strong association between the short tandem repeat polymorphism, pesticide exposure, and breast cancer development.…”

Section: Pesticides and The Link To Cancermentioning

confidence: 95%

Environmental Pesticides and Heavy Metals — Role in Breast Cancer

Wallace¹

2015

Toxicity and Hazard of Agrochemicals

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The intent of this chapter is to provide an overview to the current thoughts and ideals regarding the involvement of pesticides and heavy metals in the progress of breast cancer. The history of pesticides encompasses a few millennia, but our understanding of the pesticide action and the health consequences has only begun to develop in the last -years. Interestingly, many of these pesticides have estrogen-like activity and may be involved in the development of breast cancer. " new category of estrogen-like compounds has been identified and studied in the last years, the metalloestrogens . Heavy metals, such as cadmium, which have estrogen like activity will be discussed. Finally, we will attempt to pull together the actions of pesticides and metalloestrogens as a possible synergistic mechanism by which these toxins may work to promote breast cancer development.

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Decreased peak bone mass is associated with a 3-bp deletion/insertion of the CYP19 intron 4 polymorphism: Preliminary data from the GOOS study

Kaštelan

Grubić

Kraljević

et al. 2007

J Endocrinol Invest

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Finding that estrogen plays an important role in bone homeostasis in men prompted research on relationship of polymorphism at the CYP19 gene and the bone mass. Therefore, influence of 3-bp deletion/insertion polymorphism of CYP19 (TTTA)7 allele on the peak bone mass attainment in males was studied. Fifty-eight unrelated male participants, aged 21-35, were selected depending on the presence of (TTTA)7 (no.=19) or (TTTA)7-3 (no.=39) alleles from the initial cohort of 92 young males. Heterozygotes (TTTA)7/(TTTA)7-3 (no.=13) were not included in the analysis. Serum levels of estradiol, free testosterone, 25-hydroxyvitamin D, bone alkaline phosphatase, osteocalcin, and beta-crosslaps were measured. Bone mass was measured by DXA at the hip and at the spine. (TTTA)7-3 allele was associated with significantly lower femoral neck bone mineral density (BMD) (p=0.02). Logistic regression model indicated strong association of (TTTA)7-3 allele with low BMD in the range of osteopenia/osteoporosis (p=0.014, odds ratio 12.36, confidence intervals 1.65-92.46). In the present study association of 3-bp deletion polymorphism of the (TTTA)7 allele with decreased peak bone mass in males is reported for the first time. However, further studies are necessary to elucidate the functional relevance of this polymorphism.

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A tetranucleotide repeat polymorphism in the CYP19 gene and breast cancer susceptibility in a Greek population exposed and not exposed to pesticides

Cited by 11 publications

References 14 publications

Genetic Polymorphisms in Aromatase (CYP19) Gene and Cancer

Genetic Polymorphisms in Aromatase (CYP19) Gene and Cancer

Environmental Pesticides and Heavy Metals — Role in Breast Cancer

Decreased peak bone mass is associated with a 3-bp deletion/insertion of the CYP19 intron 4 polymorphism: Preliminary data from the GOOS study

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