A Textile-Based Microfluidic Platform for the Detection of Cytostatic Drug Concentration in Sweat Samples

Abstract

This work presents a new multilayered microfluidic platform, manufactured using a rapid and cost-effective xurography technique, for the detection of drug concentrations in sweat. Textile fabrics made of cotton and polyester were used as a component of the platform, and they were positioned in the middle of the microfluidic device. In order to obtain a highly conductive textile, the fabrics were in situ coated with different amounts of polyaniline and titanium dioxide nanocomposite. This portable microfluidic platform comprises at least three layers of optically transparent and flexible PVC foils which were stacked one on top of the other. Electrical contacts were provided from the edge of the textile material when a microfluidic variable resistor was actually created. The platform was tested in plain artificial sweat and in artificial sweat with a dissolved cytostatic test drug, cyclophosphamide, of different concentrations. The proposed microfluidic device decreased in resistance when the sweat was applied. In addition, it could successfully detect different concentrations of cytostatic medication in the sweat, which could make it a very useful tool for simple, reliable, and fast diagnostics.

Fibers/Textiles-Based Flexible Sweat Sensors: A Review

“…167,168 But now, with the advent of fibers/textiles-based flexible sweat sensors, real-time and portable detection of drug concentrations in sweat has been achieved. In 2020, Goran M. Stojanovićet al 162 designed a textile-based microfluidic platform to monitor the concentration of cytostatic drugs in sweat. The function is realized by coating PANI/TiO 2 nanocomposites on the fiber, and the highest sensitivity reaches 888.83 Ω/w/v%.…”

“…Therefore, sweat has received increasing attention in drug monitoring. − When sweat was used for drug monitoring in the early research stages, it was necessary to sample the sweat first and then analyze the sample using chromatography or mass spectrometry. , But now, with the advent of fibers/textiles-based flexible sweat sensors, real-time and portable detection of drug concentrations in sweat has been achieved. In 2020, Goran M. Stojanović et al designed a textile-based microfluidic platform to monitor the concentration of cytostatic drugs in sweat. The function is realized by coating PANI/TiO 2 nanocomposites on the fiber, and the highest sensitivity reaches 888.83 Ω/w/v%.…”

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices

“…They successfully manufactured several complex microfluidic structures via solvent casting and proved good bonding strength to different substrates without any leakage. However, when in contact with water, protein precipitation decreased the substrate transparency, leading the authors to bond the microstructured zein 89 Ulum 2016; 71 Xiao 2019; 72 Stojanović, 2020 73 • High flexibility • No transparency • Amenable to wearable applications…”

Fabrikacija I Analiza Električnih Karakteristika E-Tekstilnih Uređaja Na Bazi Co-Pani Materijala

“…Tekstilne elektrode su formirane od dve vrste materijala: a) pamuk sa manjom količinom polianilina (CO-PANI1), b) pamuk sa većom količinom polianilina (CO-PANI2). Detaljan opis materijala za elektrode prikazan je u radu [5]. Za dielektrični/izolatorski sloj korišćen je 5% nanokristalni rastvor TiO 2 u etanolu.…”