“…The resolution cell is assumed to be 0.28 9 0.28 mm 2 . Computation times are evaluated for a single core algorithms and the papers that use these algorithms in fibrosis detection (when possible): first order statistics [13,34], gray tone difference matrix [33], gray level cooccurrence matrix [7,13,34,35], multiresolution fractal dimension [7], differential box counting [8,36], morphological fractal dimension estimators [37], Fourier power spectrum [6,7], Gabor filters [12], Law's energy measures [7], texture edge co-occurrence matrix [8], phase congruency [24], and texture feature coding matrix [14]. Twelve algorithms that process the entire ROI were implemented and 234 features were computed per image.…”