The detrimental effects of excessive synthetic herbicide use on the environment and yield losses from weeds in low-input agricultural systems have made sustainable weed management imperative. In this respect, a field experiment was conducted at the Agronomy Field Laboratory (AFL) of Bangladesh Agricultural University (BAU), Mymensingh, from November 2021 to March 2022, to explore the effects of mustard crop residue extracts on weed control and yield performance of wheat. The study considered three varieties: BARI Gom-32, BARI Gom-33, and BWMRI Gom-1 and six different treatment such as, no weeding (control), recommended dose of herbicide (RDH), 90% RDH + 1:20 aqueous extract of mustard (AEM), 80% RDH + 1:20 AEM, 70% RDH + 1:20 AEM, 60% RDH + 1:20 AEM. Three replications of a randomized complete block design (RCBD) were used in the experiment. The AEM and variety significantly influenced weed population (WP) and dry weight (DW), with BWMRI Gom-1 showing the highest WP and BARI Gom-32 the lowest. BARI Gom-32 also produced the highest grain yield (GY) and other yield-contributing characteristics. The best results, including the highest numbers of effective tillers (NET) hill-1 (7.67), number of grains spike-1 (NGS) (47.67), 1000-grain weight (TGW) (57.67g), GY (5.02 t ha-1), and straw yield (SY) (6.93 t ha-1), were observed in plots treated with the RDH and the BARI Gom-32 variety, followed by 90% RDH + 1:20 AEM. These findings suggested that aqueous mustard crop residue extracts could be an effectively source to suppress WP and enhance yield.