A Theoretical Endogenous Opioid Neurobiological Framework for Co-occurring Pain, Trauma, and Non-suicidal Self-injury

Johnson, Ben; McKernan, Lindsey C.; Bruehl, Stephen

doi:10.1007/s11916-022-01043-9

Cited by 8 publications

(3 citation statements)

References 127 publications

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“… 80 Interestingly, in the theory of childhood trauma, pain and endorphins, early psychological trauma may influence the system of the HPA axis and endogenous opioids, which ultimately alter the pain perception and trigger NSSI. 81 Combining the above evidence, there might be a potential association between childhood trauma, pain perception and NSSI, but more research is needed, especially regarding MDD.…”

Section: Discussionmentioning

confidence: 99%

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Wu,

Zhang,

Chen

et al. 2023

Gen Psych

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BackgroundNon-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms of NSSI in MDD remain elusive.AimsTo review present evidence related to the potential mechanisms of NSSI in MDD.MethodsAccording to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, articles for this systematic review were searched on Medline (through PubMed), Embase (through Elsevier), PsycINFO (through OVID) and Web of Science databases for English articles, as well as China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang Data, and the Chongqing VIP Chinese Science and Technology Periodical (VIP) Databases for Chinese articles published from the date of inception to 2 August 2022. Two researchers (BW, HZ) independently screened studies based on inclusion and exclusion criteria and assessed their quality.ResultsA total of 25 157 studies were searched. Only 25 of them were ultimately included, containing 3336 subjects (1535 patients with MDD and NSSI, 1403 patients with MDD without NSSI and 398 HCs). Included studies were divided into 6 categories: psychosocial factors (11 studies), neuroimaging (8 studies), stress and hypothalamic-pituitary-adrenal (HPA) axis (2 studies), pain perception (1 study), electroencephalogram (EEG) (2 studies) and epigenetics (1 study).ConclusionsThis systematic review indicates that patients with MDD and NSSI might have specific psychosocial factors, aberrant brain functions and neurochemical metabolisms, HPA axis dysfunctions, abnormal pain perceptions and epigenetic alterations.

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Section: Discussionmentioning

confidence: 99%

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Wu,

Zhang,

Chen

et al. 2023

Gen Psych

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“…NSSI behaviors can regulate the neurobiological (ie, endogenous opioid drug systems) and psychological (ie, enhanced negative effects) systems, which are affected by childhood trauma 52 . This can result in temporary pain relief and a sustained negative reinforcement cycle associated with NSSI 52 . In recent years, opioid research on emotions has mainly focused on opioid receptors 53,54 .…”

Section: Neurobiological Mechanisms Of Emotional Dysregulation In Non...mentioning

confidence: 99%

“…Once encountering emotional stress, the low baseline level of opioids in individuals engaged in NSSI triggers them to restore opioid homeostasis through self-injurious behavior 13 . NSSI behaviors can regulate the neurobiological (ie, endogenous opioid drug systems) and psychological (ie, enhanced negative effects) systems, which are affected by childhood trauma 52 . This can result in temporary pain relief and a sustained negative reinforcement cycle associated with NSSI 52 .…”

Section: Nonsuicidal Self-injury and Emotional Dysregulationmentioning

confidence: 99%

Mechanisms and intervention strategies of emotional dysregulation in individuals with nonsuicidal self-injury

Li,

2023

Interdisciplinary Nursing Research

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Non-suicidal self-injury (NSSI) is a deliberate, direct, socially unacceptable, and nonsuicidal form of self-hurt, with a high incidence rate among adolescents. NSSI harms people’s bodies and minds, dampening their social function and increasing the risk of suicide. The Benefit and Barrier Model of NSSI proposes that the core benefit of NSSI is emotional gain, in other words, the emotion regulation effect of the NSSI behaviors. The purpose of this study was to elucidate the relationship between NSSI and emotional dysregulation, analyze the possible behavioral and neural mechanisms underlying emotional dysregulation in NSSI, and summarize the application of emotion regulation strategies in the intervention for NSSI. This review provides evidence and implications for further research on the mechanisms and interventions related to emotional dysregulation in people with NSSI.

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Child Maltreatment: Externalizing Characteristics After

Lukenda,

Johnson

2023

Encyclopedia of Domestic Violence

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A Theoretical Endogenous Opioid Neurobiological Framework for Co-occurring Pain, Trauma, and Non-suicidal Self-injury

Cited by 8 publications

References 127 publications

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review

Mechanisms and intervention strategies of emotional dysregulation in individuals with nonsuicidal self-injury

Child Maltreatment: Externalizing Characteristics After

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