Optical detection, measurement, and treatment methods are widely used in the medical industry nowadays. The evolution of radiated beams, received power and beam size play vital roles while developing devices. The propagation properties of hollow higher-order cosh-Gaussian beam (HHOCGB) while propagating in human upper dermis tissue are derived analytically and analyzed numerically. The impact of the hollowness parameter, beam order, operating wavelength, and Gaussian beam waists on the beam’s intensity profile is examined. Received power and beam size variations are analyzed considering operating wavelength and Gaussian waist width. According to the results, as the beam propagates, its profile rapidly evolves into a shape with a circular Gaussian peak in the center and petals at the corner. Dark hollow regions are observed among the petals. Furthermore, the received power by HHOCGBs with a higher Gaussian waist width is more than those received by beams with a lower Gaussian waist width. However, at far field, operating at a lower wavelength prevents the increase of the beam spread. Thus, the obtained results will be significant in the bio-optical disease detection and treatment technology development.