A thermal analysis study of Ibuprofen

Lerdkanchanaporn, Supaporn; Dollimore, D.

doi:10.1007/bf01996773

Cited by 51 publications

(43 citation statements)

References 7 publications

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“…So, E act and ln A were obtained to be 80.33 ± 1.44 kJ mol −1 and 20.49 ± 1.24, respectively, by four repeat measurements. These results are in good agreement with [2] which reported E act and ln A were 81.9 kJ mol −1 and 20.7, respectively.…”

Section: The Results Of Tg and Thermodynamic Study For Ibuprofensupporting

confidence: 92%

“…Ibuprofen, chemically named as 2-(4-isobutylphenyl)-propionic acid (molar mass: 206.28 g mol −1 ), a white crystal and non-steroidal anti-inflammatory drug having analgesic and antipyretic activities, shows a melting process at 75-77 • C [1] The earlier investigation [2] has indicated that the evaporation of ibuprofen was a zero-order process. The activation energy and enthalpy of vaporization were found to be 81.…”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Sun

Tan

et al. 2004

Thermochimica Acta

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Section: The Results Of Tg and Thermodynamic Study For Ibuprofensupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Sun

Tan

et al. 2004

Thermochimica Acta

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“…The endothermic peak at 76.2 °C and the absence of loss of mass in the TGA indicate that it is the melting point of ibuprofen which is the charcteristics of racemic ibuprofen. This is in agreement with the previous works of Tita et al [29] and Lerdkanchanaporn et al [30]. The other peak at 255 °C indicates the boiling point.…”

Section: Tga/dtasupporting

confidence: 91%

Growth, spectral and thermal studies of ibuprofen crystals

Ramukutty

Ramachandran

2011

Cryst. Res. Technol.

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Key words ibuprofen, gel growth, FTIR, UV-Vis, TGA/DTA. RS-Ibuprofen was crystallized for the first time in silica gel under suitable pH conditions by reduction of solubility method. The grown crystals were characterized by single crystal X-ray diffraction and density measurement. The functional groups present in the crystal were identified using Fourier transform infrared spectroscopy. Optical bandgap energy of ibuprofen was estimated as 3.19(3) eV from UV-Vis spectrum. Thermogravimetric analysis revealed that ibuprofen is thermally stable upto 102.9 °C and the initial loss of mass was due to evaporation only. Morphological study showed that the growth is prominent along b-axis and the prominent face is {100}.

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“…[32] In addition, we considered the aggregation contribution, which takes place in ad ifferent manner between the two environments and is common in several commonly-used drugs. [33,34] This approachrepresents the possibility to predict release behavior,a nd therefore, to improve medicalprospects.…”

Section: Introductionmentioning

confidence: 99%

The Role of Drug–Drug Interactions in Hydrogel Delivery Systems: Experimental and Model Study

et al. 2016

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To address the increasing need for improved tissue substitutes, tissue engineering seeks to create synthetic, three-dimensional scaffolds made from polymeric materials able to incorporate cells and drugs. The interpretation of transport phenomena is a key step, but comprehensive theoretical data is still missing and many issues related to these systems are still unsolved. In particular, the contribution of solute-solute interactions is not yet completely understood. Here, we investigate a promising agar-carbomer (AC) hydrogel loaded with sodium fluorescein (SF), a commonly used drug mimetic. The self-diffusion coefficient of SF in AC formulations was measured by using high resolution magic angle spinning NMR spectroscopy (HR-MAS NMR). Starting from experimental data, a complete overview on SF transport properties is provided, in particular a mathematical model that describes and rationalizes the differences between gel and water environments is developed and presented. The hydrogel molecular environment is able to prevent SF aggregation, owing to the adsorption mechanism that reduces the number of monomers available for oligomer formation at low solute concentration. Then, when all adsorption sites are saturated free SF molecules are able to aggregate and form oligomers. The model predictions satisfactorily match with experimental data obtained in water and the gel environment, thus indicating that the model presented here, despite its simplicity, is able to describe the key phenomena governing device behavior and could be used to rationalize experimental activity.

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A thermal analysis study of Ibuprofen

Cited by 51 publications

References 7 publications

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis

Growth, spectral and thermal studies of ibuprofen crystals

The Role of Drug–Drug Interactions in Hydrogel Delivery Systems: Experimental and Model Study

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