A thermal analysis study of dialkyldithiocarbamato nickel(II) and copper(II) complexes

Ali, Basem F.; Al-Akramawi, W.S.; Al-Obaidi, K. H.; Al-Karboli, A.H.

doi:10.1016/j.tca.2004.01.022

Cited by 31 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, thermal decomposition of zinc(II) complexes 1c and 3c is essentially taking place in a single stage giving a broad exothermic peak on DTA curve. The thermal data is consistent with the literature report where a thermal decomposition of similar dialkyldithiocarbamate transition metal (II) complexes proceeds in several stages involving many exothermic processes.…”

Section: Resultssupporting

confidence: 91%

Derivatives of Dapsone (dap): Synthesis and Study on In Vitro Anticancer Activity and DNA Laddering Against Hep G2 and C6 Human Cancer Cell Lines

et al. 2017

View full text Add to dashboard Cite

Interesting biological profile of dapsone (dap) has encouraged us to derivatize it further into a novel series of diamines 4,4’‐bis(2‐(alkylamino) acetamido) diphenylsulfone L1‐L3 and their ensuing metallomacrocyclic complexes of the type [M2‐μ2‐bis‐{(κ2S,S‐S2CN(R)CH2CONHC6H4)2SO2}] {R=Cy, M=NiII 1 a, CuII 1 b, ZnII 1 c; R=iPr, M=NiII 2 a, CuII 2 b, ZnII 2 c; R=nBu, M=NiII 3 a, CuII 3 b, ZnII 3 c}. These compounds were characterized by standard spectroscopic methods. A DFT level calculation has been performed on selected compounds. In vitro anticancer activity against Hep G2 (hepatoma) and C6 (Glioblastoma) cell lines suggests specificity of these compounds for cancer cells over normal liver cells. Interestingly, complex 2c holding zinc(II) and N‐iPr substituents shows nearly 3 fold better cytotoxic activity against both Hep G2 (8.47±0.016 μg/mL) and C6 (4.3±0.019 μg/mL) cell lines, compared to the reference drug Cisplatin. The morphological changes and moderate to heavy DNA laddering clearly demonstrate the induction of apoptotic cell death, required for major chemical therapeutic implications.

show abstract

Section: Resultssupporting

confidence: 91%

Derivatives of Dapsone (dap): Synthesis and Study on In Vitro Anticancer Activity and DNA Laddering Against Hep G2 and C6 Human Cancer Cell Lines

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The heating rate was suitably controlled at 10 °C min −1 under nitrogen atmosphere. Similar to other transition metal dithiocarbamate complexes, a multistage mass loss on corresponding DTG curves and DTA peaks due to endothermic and/or exothermic elimination of molecular fragments can be clearly seen on thermogravimetric plots for these compounds (Figure S58). Notably, thermal decompositions of all the complexes start before their melting points.…”

Section: Resultsmentioning

confidence: 59%

Improving Cytotoxicity by Changing a Linker from Diphenylether to Diphenylmethane and now to Phenylene in Binuclear Dithiocarbamate Complexes: Synthesis and Cytotoxicity Study

et al. 2019

View full text Add to dashboard Cite

α‐chloroamide 1,3‐bis(2‐chloroacetamido)phenylene (L’) is selected as a lead compound to derive 1,3‐bis(2‐(alkylamino)acetamido)phenylene (L1‐L3). A programmed self‐assembly involving L1‐L3, CS2 and NiII, CuII or ZnII ions affords access to a new series of 32‐membered binuclear macrocyclic dithiocarbamates [MII2‐μ2‐bis‐{(κ2S,S‐S2CN(R)CH2CONH)2C6H4}]{R=Cy, M=NiII 1 a, CuII 1 b, ZnII 1 c; R=iPr, M=NiII 2 a, CuII 2 b, ZnII 2 c; R=nBu, M=NiII 3 a, CuII 3 b, ZnII 3 c}. Compounds were characterized by spectroscopic (1H, 13C, DEPT 135, 1H DOSY NMR, HRMS/ESI MS, UV‐visible, Fluorescence, IR) and by the TGA. Evidently, L’ forms a fascinating 2D infinite supramolecular molecular sheet. All the compounds were screened for their in vitro cytotoxic activity against malignant tumor Hep G2 (hepatoma) cell line by the MTT assay. A majority of compounds ca L’, L1, 1 a, 1 b, 1 c, 2 a, 2 b, 2 c, L3,3 a, 3 b, 3 c display IC50 values lower than cisplatin and specificity for carcinoma Hep G2 over normal liver cell line (WRL‐68). Evidently cytotoxic potentials of L1‐L3 improved tremendously upon formation of their corresponding bimetallic dithiocarbamate complexes. The shrinking of cells can be clearly visualized by acridine orange/ethidium bromide (AO/EB) staining indicating the induction of apoptosis as part of the mechanism of action of these compounds. Further, DFT level calculations have been performed on representative compounds to reinforce the experimental results.

show abstract

“…At the end of the first stage of decomposition, piperidine and pyrrolidine substituted complexes are left with 36 and 50% weights, respectively. It seems at some stage during decomposition ring opening followed by molecular rearrangement may be taking place as suggested by other workers [22,23]. Alternatively it may also involve loss of pyrrolidine/piperidine ring substituents along with evolution of CS 2 as suggested in literature [2].…”

Section: Thermogravimetric Studiesmentioning

confidence: 69%

Synthesis of tris(N,N′-dialkyldithiocarbamato) iron(III) complexes and their thermal decomposition studies by various techniques

Singhal¹,

Garg

Chandra

2007

Journal of Alloys and Compounds

View full text Add to dashboard Cite

A thermal analysis study of dialkyldithiocarbamato nickel(II) and copper(II) complexes

Cited by 31 publications

References 12 publications

Derivatives of Dapsone (dap): Synthesis and Study on In Vitro Anticancer Activity and DNA Laddering Against Hep G2 and C6 Human Cancer Cell Lines

Derivatives of Dapsone (dap): Synthesis and Study on In Vitro Anticancer Activity and DNA Laddering Against Hep G2 and C6 Human Cancer Cell Lines

Improving Cytotoxicity by Changing a Linker from Diphenylether to Diphenylmethane and now to Phenylene in Binuclear Dithiocarbamate Complexes: Synthesis and Cytotoxicity Study

Synthesis of tris(N,N′-dialkyldithiocarbamato) iron(III) complexes and their thermal decomposition studies by various techniques

Contact Info

Product

Resources

About