Herein, an improved thermal‐mechanical coupled analysis is used to increase the calculation efficiency of the detailed laser melting deposition (LMD) process. By optimizing the loading process of the laser heat source and lumping several deposited layers into an equivalent numerical layer, the efficiency is significantly improved. The calculation time is saved by 85% when lumping six layers. Compared with the experimental data, the minimum deviation of predicted maximum distortion reaches 3.2% when lumping four layers. A multiscale method is proposed to predict the distortion result of the large‐sized part efficiently. In this method, the optimal heights of equivalent numerical layers are explored. The comparisons with the experimental result show that the optimal heights of equivalent numerical layers are 1 and 1.5 mm in view of accuracy and efficiency. Based on the multiscale method, the residual distortion of the substrate after depositing a large‐sized eight‐layer line deposition structure is accurately predicted. The deviations of the maximum distortion predicted by the improved thermal‐mechanical coupled simulation and the multiscale method are 3.26% and 6.12%, respectively. Moreover, the calculation time of the latter is 98.8% less than that of the former.