A thermosensitive hydrogel formulation of phage and colistin combination for the management of multidrug-resistant <i>Acinetobacter baumannii</i> wound infections

Mukhopadhyay, Subhankar; To, Kenneth K. W.; Liu, Yannan; Bai, Changqing; Leung, Sharon S. Y.

doi:10.1039/d3bm01383a

Cited by 8 publications

(1 citation statement)

References 67 publications

(104 reference statements)

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“…It has garnered considerable attention as a material for wound dressings and drug depots for prolonged drug release [54]. Recently, hydrogels have been engineered to incorporate phages for the treatment of wound infections [55,56]. Yan et al conducted a study to evaluate the effectiveness of a phage-loaded thermosensitive hydrogel in addressing wound infections induced by MDR A. baumannii using pig skin.…”

Section: Clinical Application Of Phage Therapy To Treat Refractory Wo...mentioning

confidence: 99%

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

Wang,

Du,

Dong

et al. 2024

IJMS

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Wound infection is one of the most important factors affecting wound healing, so its effective control is critical to promote the process of wound healing. However, with the increasing prevalence of multi-drug-resistant (MDR) bacterial strains, the prevention and treatment of wound infections are now more challenging, imposing heavy medical and financial burdens on patients. Furthermore, the diminishing effectiveness of conventional antimicrobials and the declining research on new antibiotics necessitate the urgent exploration of alternative treatments for wound infections. Recently, phage therapy has been revitalized as a promising strategy to address the challenges posed by bacterial infections in the era of antibiotic resistance. The use of phage therapy in treating infectious diseases has demonstrated positive results. This review provides an overview of the mechanisms, characteristics, and delivery methods of phage therapy for combating pathogenic bacteria. Then, we focus on the clinical application of various phage therapies in managing refractory wound infections, such as diabetic foot infections, as well as traumatic, surgical, and burn wound infections. Additionally, an analysis of the potential obstacles and challenges of phage therapy in clinical practice is presented, along with corresponding strategies for addressing these issues. This review serves to enhance our understanding of phage therapy and provides innovative avenues for addressing refractory infections in wound healing.

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Section: Clinical Application Of Phage Therapy To Treat Refractory Wo...mentioning

confidence: 99%

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

Wang,

Du,

Dong

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Bacteriophage entrapment strategies for the treatment of chronic wound infections: a comprehensive review

Mohan,

Bosco,

Peter

et al. 2024

Arch Microbiol

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Phage-Based antibacterial hydrogels for bacterial targeting and Ablation: Progress and perspective

Bai,

Borjihan,

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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A thermosensitive hydrogel formulation of phage and colistin combination for the management of multidrug-resistant Acinetobacter baumannii wound infections

Abstract: Chronic skin wounds are often associated with multidrug-resistant bacteria, impeding the healing process. Bacteriophage (phage) therapy has been revitalized as a promising alternative to antibiotics. However, phage monotherapy also faces...

Cited by 8 publications

References 67 publications

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

Current Knowledge and Perspectives of Phage Therapy for Combating Refractory Wound Infections

Bacteriophage entrapment strategies for the treatment of chronic wound infections: a comprehensive review

Phage-Based antibacterial hydrogels for bacterial targeting and Ablation: Progress and perspective

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