2022
DOI: 10.1111/ajt.16933
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A third dose of SARS-CoV-2 vaccine increases neutralizing antibodies against variants of concern in solid organ transplant recipients

Abstract: Vaccine‐induced SARS‐CoV‐2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS‐CoV‐2 vaccine doses increase anti‐spike IgG in some SOTRs, but it is uncertain whether neutralization of variants of concern (VOCs) is enhanced. We tested 47 SOTRs for clinical and research anti‐spike IgG, pseudoneutralization (ACE2 blocking), and live‐virus neutralization (nAb) against VOCs before and after a third SARS‐CoV‐2 vaccine dose (70% m… Show more

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Cited by 89 publications
(93 citation statements)
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“…Moreover the third SARS-CoV-2 vaccine dose seems to increase the activity of neutralization againts VOCs also in the immunocompromised patients [25][26]. Garcia-Beltram and colleagues have demonstrated that the mRNA-based COVID-19 vaccine boosters induce a significantly greater humoral immune response against all the variants [26].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover the third SARS-CoV-2 vaccine dose seems to increase the activity of neutralization againts VOCs also in the immunocompromised patients [25][26]. Garcia-Beltram and colleagues have demonstrated that the mRNA-based COVID-19 vaccine boosters induce a significantly greater humoral immune response against all the variants [26].…”
Section: Discussionmentioning
confidence: 99%
“…Experience, thus far, supports the use of an FDA authorized semi or fully quantitative anti‐spike assay 41 validated in vaccinated, immunocompromised persons via neutralization testing (preferably live virus). 27 , 42 , 43 Reporting anti‐spike values in binding antibody units (BAU), normalized to the WHO international standard would also help reduce heterogeneity and confusion among assays ( https://www.who.int/publications/m/item/WHO‐BS‐2020.2403 ). Several clinical platforms have established conversion factors to BAU, which can either be directly used or correlated to other assays if binding the same target.…”
Section: Strategies To Improve Protection Versus Covid‐19mentioning
confidence: 99%
“…However, importantly, two recent studies demonstrated that 25-68% of solid organ transplant recipients had detectable neutralizing Ab against the Delta variant after the third dose of mRNA vaccine (versus 100% of healthy controls) (143,144). Further, none of 51 kidney transplant recipients had detectable neutralizing Ab against the Omicron variant (144).…”
Section: Third Vaccine Dosesmentioning
confidence: 99%