A thirteen week ad libitum administration toxicity study of Tartrazine in Swiss mice

Mehedi, Nabila; Mokrane, Nawel; Alami, Omar; Ainad-Tabet, S.; Zaoui, Chahinaize; Khéroua, O.; Saïdi, D.

doi:10.5897/ajb2013.12125

Cited by 34 publications

(8 citation statements)

References 37 publications

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“…In addition, these results are in agreement with data reported by Amin, Abdel Hameid & AbdElsttar (2010) who revealed a significant increase in serum creatinine and urea levels in rats after consumption of tartrazine. Recently, Nabila et al (2013) mentioned that tartrazine application induced significant elevations in urea and creatinine levels that is associated with impaired renal function and the inability of the kidney to filter body fluids.…”

Section: Discussionmentioning

confidence: 99%

Tartrazine induces structural and functional aberrations and genotoxic effectsin vivo

Khayyat

Essawy

Sorour

et al. 2017

PeerJ

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Tartrazine is a synthetic organic azo dye widely used in food and pharmaceutical products. The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into two groups of 10 each, control- and tartrazine-treated groups. The control group was administered orally with water alone. The experimental group was administered orally with tartrazine (7.5 mg/kg, b.wt.). Our results showed a marked increase in the levels of ALT, AST, ALP, urea, uric acid, creatinine, MDA and NO, and a decreased level of total antioxidants in the serum of rats dosed with tartrazine compared to controls. On the other hand, administration of tartrazine was associated with severe histopathological and cellular alterations of rat liver and kidney tissues and induced DNA damage in leucocytes as detected by comet assay. Taken together, the results showed that tartrazine intake may lead to adverse health effects.

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Section: Discussionmentioning

confidence: 99%

Tartrazine induces structural and functional aberrations and genotoxic effectsin vivo

Khayyat

Essawy

Sorour

et al. 2017

PeerJ

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show abstract

“…As reported by Sasaki et al using a comet assay, tartrazine that was applied at a dose of 7.5 mg/kg could induce DNA damage in the colon of mice [22]. Nabila Mehedi et al concluded that tartrazine applied in drinking water at the different low doses induced depression of body weight and adverse effects on the organs of Swiss mice [31]. Moreover, lesions in the brain, liver, and kidneys in animals treated with tartrazine were observed.…”

Section: Discussionmentioning

confidence: 81%

“…In the study realized by Mehedi et al [31] was demonstrated that sub-chronic ingestion of tartrazine at low doses added in water could cause a structural alteration of the spleen and intestine, inducing a depressing effect on the humoral immune response in male mice. According to recent findings [28,32] tartrazine is able to generate ROS (reactive oxygen species), accelerating oxidative stress, modifying the biochemical profiles and structure in the renal and hepatic tissues.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats

Balta¹,

Sevastre²,

Mireşan³

et al. 2019

Preprint

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Background: Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causingagitation, confusion, rhinitis and can produce hyperactivity syndrome in children when is combined with benzoates.Additionally, it can trigger oxidative stress which consequently generates metabolic disorders. Therefore, the studywas designed to evaluate the harmful effects of the food additive tartrazine and to observe beneficial properties ofblackthorn fruits (Prunus spinosa) on the blood and organs of albino Wistar rats.Materials and methods: This study was carried out on 20 mature Wistar rats, randomly divided into four groupsof five animals. Over the course of the experiment, the control group received only food and drinking water, group Ireceived 75 mg of tartrazine dissolved in (250 ml) water group II was given 75 mg of tartrazine and 200 mg of driedblackthorn fruit powder 200 mg dissolved simultaneously in (250 ml) of tartrazine-water mixture (aiming to reducethe tartrazine toxicity) and group III received a higher dose of tartrazine (100 mg) in (250 ml) of water.Results: At the end of the experiment, values regarding kidney and liver weight were significantly increased, whilethe weight of the spleen was slightly decreased compared with the weight of the control group. Biochemical andhematological assays, of the blood samples show that the addition of tartrazine in the diet of rats caused significantchanges in all biochemical and hematological parameters of the blood. In the group II, which received (P. spinosa)powder combined with tartrazine, the biochemical and hematological parameters had average values similar to thecontrol group.Conclusions: Histopathological assay showed that the application of tartrazine in the group I, II and III producedlesions of the kidneys, spleen and the liver for all rodents. Tartrazine was able to generate histopathological changes,which caused significantly tissue lesions of the liver and significant changes in blood parameters. Blackthorn powdershowed a promising protective role for the blood parameters but demonstrated no significant benefits for the organs.

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“…In addition, these results are in agreement with data reported by Amin et al (2010) who revealed a significant increase in serum creatinine and urea levels in rats after consumtion of tartrazine. Recently, Nabila et al(2013) mentioned that tartrazine application induced significant elevations in urea and creatinine levels that is associalted with impared renal function and the inability of the kidney to filter body fluids.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Tartrazine induces structural and functional aberrations and genotoxic effects in vivo (v0.1)"

2017

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The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into 2 groups of 10 each, control-and tartrazine-treated groups. The control group was administered orally with water alone. The experimental group was administered orally with tartrazine (7.5 mg/kg, b.wt.). Our results showed a marked increase in the levels of ALT, AST, ALP, urea, uric acid, creatinine, MDA and NO, and a decreased level of total antioxidants in the serum of rats dosed with tartrazine compared to controls. On the other hand, administration of tartrazine was associated with severe histopathological and cellular alterations of rat liver and kidney tissues and induced DNA damage in leucocytes as detected by comet assay. Taken together, the results showed that tartrazine intake may leads to an adverse health effects.

show abstract

A thirteen week ad libitum administration toxicity study of Tartrazine in Swiss mice

Cited by 34 publications

References 37 publications

Tartrazine induces structural and functional aberrations and genotoxic effectsin vivo

Tartrazine induces structural and functional aberrations and genotoxic effectsin vivo

Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats

Peer Review #1 of "Tartrazine induces structural and functional aberrations and genotoxic effects in vivo (v0.1)"

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