A three‐dimensional (3D) two‐way coupled fluid‐structure interaction (FSI) study of peristaltic flow in obstructed ureters

Takaddus, Ahmed Tasnub; Chandy, Abhilash J.

doi:10.1002/cnm.3122

Cited by 17 publications

(5 citation statements)

References 33 publications

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“…Takaddus and Chandy (2018) presented the first full three‐dimensional FSI model on obstructed ureters with peristaltic waves. The ureter is modeled as a 30 cm long tube with its two ends fixed, and the stone is modeled as a fixed spherical obstruction of varying size.…”

Section: Methodsmentioning

confidence: 99%

Fluid mechanical modeling of the upper urinary tract

Zheng

Carugo

Mosayyebi

et al. 2021

WIREs Mechanisms of Disease

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The upper urinary tract (UUT) consists of kidneys and ureters, and is an integral part of the human urogenital system. Yet malfunctioning and complications of the UUT can happen at all stages of life, attributed to reasons such as congenital anomalies, urinary tract infections, urolithiasis and urothelial cancers, all of which require urological interventions and significantly compromise patients' quality of life. Therefore, many models have been developed to address the relevant scientific and clinical challenges of the UUT. Of all approaches, fluid mechanical modeling serves a pivotal role and various methods have been employed to develop physiologically meaningful models. In this article, we provide an overview on the historical evolution of fluid mechanical models of UUT that utilize theoretical, computational, and experimental approaches. Descriptions of the physiological functionality of each component are also given and the mechanical characterizations associated with the UUT are provided. As such, it is our aim to offer a brief summary of the current knowledge of the subject, and provide a comprehensive introduction for engineers, scientists, and clinicians who are interested in the field of fluid mechanical modeling of UUT. This article is categorized under: Cancer > Biomedical Engineering Infectious Diseases > Biomedical Engineering Reproductive System Diseases > Biomedical Engineering

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Section: Methodsmentioning

confidence: 99%

Fluid mechanical modeling of the upper urinary tract

Zheng

Carugo

Mosayyebi

et al. 2021

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

show abstract

“…The ureter wall is supposed as a no-slip structure with no urine penetration through it. On both ends of the ureter, constant pressure is set with a pressure difference of 0.3 Pa. [37][38][39][40][41] The peristaltic motion is considered to be a sinusoidal contraction wave moving with a constant velocity of c along the ureter wall. The equation of peristaltic movement is assumed as (1):…”

Section: Geometry and Boundary Conditionsmentioning

confidence: 99%

“…The results specifically showed the trapping and reflux disorders in the absence of stone. Takaddus et al 40,41 performed numerical simulations of peristalsis in an obstructed ureter using a two-way coupling FSI with the arbitrary Eulerian-Lagrangian method to understand the urine transport process. The results of these studies showed the trapping and reflux disorders in the absence of stone and an increase in ureter wall shear stress and pressure gradient values in the fluid with the larger size of the obstruction.…”

Section: Introductionmentioning

confidence: 99%

Numerical analysis of an obstacle motion in the human ureter using the dynamic mesh approach

Abbasian,

Maddahian

2024

Numer Methods Biomed Eng

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Peristalsis is a common motion in various biological systems, especially the upper urinary tract, where it plays a pivotal role in conveying urine from the kidneys to the bladder. Using computational fluid dynamics, this study aims to investigate the effect of various peristaltic parameters on the motion of an obstacle through a two‐dimensional ureter. Methodologically, Incompressible Navier–Stokes equations were utilized as the fluid domain's governing equations, and the Dynamic Mesh method (DM) was employed to simulate the peristaltic and obstacle motion. The peristaltic motion was modeled by a sinusoidal contraction wave propagating alongside the ureter at the physiological speed, and the motion of the obstruction through the ureter, which is caused by the fluid forces applied on its surface, was explored using the equation of Newton's second law. Various test cases of different shapes and sizes were supposed as kidney stones to understand the influence of the peristalsis properties on the stone removal process. The results show that the motion of the kidney stone is highly influenced by the gradient pressure force applied to its surface in the fluid domain. Moreover, investigating the effects of the peristaltic physical properties on the obstacle's motion indicates that the stone's motion is dependent on these parameters. Furthermore, this analysis provides insight into the peristaltic motion effects, assisting physicians in developing new medicines to facilitate the kidney stone removal process based on its shape and size.

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“…For an effective model of the distension contraction waves, a piecewise linear force function is introduced. Takaddus and Chandy [4] use the Eulerian-Lagrangian method for the fluid-structure interaction (FSI) of the urine with the tube wall for the estimation of the effect of the size of obstructions.…”

Section: Introductionmentioning

confidence: 99%

Multivariate Peristalsis in a Straight Rectangular Duct for Carreau Fluids

Moulinos,

Manopoulos,

Tsangaris

2024

Computation

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Peristaltic flow in a straight rectangular duct is examined imposed by contraction pulses implemented by pairs of horizontal cylindrical segments with their axes perpendicular to the flow direction. The wave propagation speed is considered in such a range that triggers a laminar fluid motion. The setting is analyzed over a set of variables which includes the propagation speed, the relative occlusion, the modality of the squeezing pulse profile and the Carreau power index. The numerical solution of the equations of motion on Cartesian meshes is grounded in the immersed boundary method. An increase in the peristaltic pulse modality leads to the reduction in the shear rate levels on the central tube axis and to the movement of the peristaltic characteristics to higher pressure values. The effect of the no slip side walls (NSSWs) is elucidated by the collation with relevant results for the flow field produced under the same assumptions though with slip side walls (SSWs). Shear thinning behavior exhibits a significantly larger effect on transport efficiency for the NSSWs duct than on the SSWs duct.

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A three‐dimensional (3D) two‐way coupled fluid‐structure interaction (FSI) study of peristaltic flow in obstructed ureters

Cited by 17 publications

References 33 publications

Fluid mechanical modeling of the upper urinary tract

Fluid mechanical modeling of the upper urinary tract

Numerical analysis of an obstacle motion in the human ureter using the dynamic mesh approach

Multivariate Peristalsis in a Straight Rectangular Duct for Carreau Fluids

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