A Three-Dimensional Computed Tomographic Analysis of the Cervical Spine in Unoperated Infants with Cleft Lip and Palate

Rajion, Zainul Ahmad; Townsend, Grant; Netherway, David J.; Anderson, Peter J.; Yusof, Asilah; Hughes, Toby; Shuaib, Ibrahim Lutfi; Halim, Ahmad Sukari; Samsudin, Abdul Rani; David, David J.

doi:10.1597/05-023

Cited by 29 publications

(38 citation statements)

References 23 publications

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“…[4][5][6][7][8][9][10][11][12] In this study, the occurrence of types of CVA in subjects with TMD was investigated and compared with the occurrence of CVA in a control group without TMD.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, several dental and skeletal malocclusions, as well as some congenital anomalies, have been related to anomalies of the cervical vertebral column. [4][5][6][7][8][9][10][11][12] On the other hand, it has been reported that variations of cervical column morphology also occur in healthy subjects with neutral occlusion and normal craniofacial morphology. 11 In our study, the control group was obtained from an orthodontic population to avoid any additional radiographic exposure to subjects as lateral cephalometric radiograph is a routine procedure required for orthodontic treatment planning.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, if the control group had consisted of subjects with Class I only; we could not evaluate the effect of TMD on CVA because the occurrence might depend on other types of skeletal malocclusions as well, as has been reported in the literature. [4][5][6][7][8][9][10][11][12] It would have been better if the study group had included more subjects with skeletal Class I malocclusion. However, most of the patients with TMD had either skeletal Class II or Class III malocclusion.…”

Section: Discussionmentioning

confidence: 99%

“…To date, CVAs have been related to cleft lip and palate, [4][5][6] condylar hypoplasia, 7 skeletal deep bite, 8 skeletal open bite, 9 transverse maxillary deficiency (TMD), 10 skeletal maxillary overjet, 11 skeletal mandibular overjet, 12 craniosynostosis syndromes, 13,14 and some craniofacial syndromes, such as KlippelFeil, Saethre-Chotzen, and Down syndromes. [15][16][17] On the other hand, anomalies in the cervical column morphology occur in healthy subjects with neutral occlusion and normal craniofacial morphology as well as subjects with craniofacial syndromes and severe malocclusion.…”

Section: Introductionmentioning

confidence: 99%

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Cervical Vertebral Anomalies in Patients With Transverse Maxillary Deficiency

Altan¹,

Zorkun²

2014

Turkish Journal of Orthodontics

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Objective: The literature indicates a correlation between vertebral morphologic anomalies and some orthodontic malocclusions. The aim of this study was to examine the occurrence of the types of cervical vertebral anomalies (CVAs) in subjects with transverse maxillary deficiency (TMD) and to compare this with the occurrence of CVA in a control group without TMD. Materials and Method: A sample of 47 Turkish patients (17 boys, 30 girls) with TMD and another sample of 47 Turkish patients (15 boys, 32 girls) with adequate maxillary transversal dimensions was studied. A visual assessment of the cervical column was made using lateral cephalometric films. Characteristics of the cervical column were classified according to Sandham as fusions and posterior arch deficiencies of C1 (PADs). Clinically normal appearance was determined when the first 4 vertebrae could be traced as separate entities with all anatomic components present. Differences in occurrence of CVA between the groups and between genders were assessed by v 2 independence test. Results: In the TMD group, 10,6% of the subjects had fusion in the cervical column, and 14,9% had PAD. In the control group, 17% of the subjects had fusion of the cervical column, and 8,5% had PAD. The occurrence of PAD was significantly increased in the TMD group (p,0.05), while no significant difference was found between the groups for occurrence of fusion (p.0.05). No statistically significant gender differences were found in the occurrence of CVA in the TMD group and the control group (p.0.05). Conclusion: No difference was found in the occurrence of fusion between the subjects with TMD and the subjects without TMD, and the occurrence of PAD was significantly increased in subjects with TMD. (Turkish J Orthod. 2015;27:136-142)

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“…[4][5][6][7][8][9][10][11][12] In this study, the occurrence of types of CVA in subjects with TMD was investigated and compared with the occurrence of CVA in a control group without TMD.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cervical Vertebral Anomalies in Patients With Transverse Maxillary Deficiency

Altan¹,

Zorkun²

2014

Turkish Journal of Orthodontics

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“…Otros reportan variaciones anatómicas en cuanto a la formación de la columna cervical, cuando se comparan con niños que no presentan ningún tipo de malformación (3). Estudios realizados por el grupo de Baccetti, Franchi y McNamara muestran que es importante un diagnóstico previo del estado de maduración ósea para tomar la decisión de iniciar la intervención de algunas maloclusiones importantes, como las clases II y III esqueléticas.…”

Section: Introductionunclassified

Maturation State of Cervical Vertebrae Bone in a Colombian Population with or without Cleft Lip and Palate

Carrera

Martínez²,

Díaz

et al. 2014

Univ Odontol

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Exploring copy number variants in deceased fetuses and neonates with abnormal vertebral patterns and cervical ribs

Schut

Brosens

Dooren

et al. 2020

Birth Defects Research

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Background: Cervical patterning abnormalities are rare in the general population, but one variant, cervical ribs, is particularly common in deceased fetuses and neonates. The discrepancy between the incidence in the general population and early mortality is likely due to indirect selection against cervical ribs. The cause for the co-occurrence of cervical ribs and adverse outcome remains unidentified. Copy number variations resulting in gain or loss of specific genes involved in development and patterning could play a causative role. Methods: Radiographs of 374 deceased fetuses and infants, including terminations of pregnancies, stillbirths and neonatal deaths, were assessed. Copy number profiles of 265 patients were determined using single nucleotide polymorphism array. Results: 274/374 patients (73.3%) had an abnormal vertebral pattern, which was associated with congenital abnormalities. Cervical ribs were present in 188/374 (50.3%) and were more common in stillbirths (69/128 [53.9%]) and terminations of pregnancies (101/188 [53.7%]), compared to live births (18/58, 31.0%). Large (likely) deleterious copy number variants and aneuploidies were prevalent in these patients. None of the rare copy number variants were recurrent or overlapped with candidate genes for vertebral patterning. Conclusions: The large variety of copy number variants in deceased fetuses and neonates with similar abnormalities of the vertebral pattern probably reflects the etiological heterogeneity of vertebral patterning abnormalities. This genetic heterogeneity corresponds with the hypothesis that cervical ribs can be regarded as a sign of disruption of critical, highly interactive stages of embryogenesis. The vertebral pattern can probably provide valuable information regarding fetal and neonatal outcome.

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A Three-Dimensional Computed Tomographic Analysis of the Cervical Spine in Unoperated Infants with Cleft Lip and Palate

Abstract: There was evidence for subtle upper spinal anomalies in the infant cleft lip and palate population. Our finding of reduced size of some cervical vertebral bodies may reflect delayed upper spinal development in infants with cleft lip and palate.

Cited by 29 publications

References 23 publications

Cervical Vertebral Anomalies in Patients With Transverse Maxillary Deficiency

Cervical Vertebral Anomalies in Patients With Transverse Maxillary Deficiency

Maturation State of Cervical Vertebrae Bone in a Colombian Population with or without Cleft Lip and Palate

Exploring copy number variants in deceased fetuses and neonates with abnormal vertebral patterns and cervical ribs

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