A three-dimensional digital segmented and deformable brain atlas of the domestic pig

Saïkali, Stéphan; Meurice, Paul; Sauleau, Paul; Éliat, Pierre-Antoine; Bellaud, Pascale; Randuineau, Gwénaëlle; Vérin, Marc; Malbert, Charles‐Henri

doi:10.1016/j.jneumeth.2010.07.041

Cited by 149 publications

(183 citation statements)

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“…Anatomical brain imaging studies on pigs have allowed the identification of swine cerebral structures and the conception of stereotaxic atlases of the pig brain (e.g. Felix et al, 1999;Watanabe et al, 2001;Saikali et al, 2010). Thanks to these atlases, numerous anatomical brain analogies between pigs and humans have been highlighted.…”

Section: Neurobiological Similaritiesmentioning

confidence: 99%

mentioning

confidence: 99%

“…The human model was obtained from the website http://www.brainvisa.info/museum.html. The pig model was obtained from a stereotactic 3D atlas realized in our institution (Saikali et al, 2010). negatively conditioned through the ingestion of a flavoured meal coupled with an intraduodenal injection of NaCl (sham treatment) or lithium chloride, respectively. The brain activations were then explored via SPECT during olfacto-gustatory stimulations with the conditioned flavours.…”

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confidence: 99%

“…(b) Skinned back view of the pig brain with 3D-representations of several structures of the 'brain reward system' including the nucleus accumbens (ACC), the globus pallidus (GP), the putamen (PUT) and the caudate nucleus (CAU). All these images were obtained from a stereotactic 3D atlas realized in our institution (Saikali et al, 2010). In the top left corner of each part of the figure (a and b), complete 3D models of the pig brain in the same orientation as the skinned representations are shown (F 5 front; b 5 back; R 5 right; L 5 left).…”

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Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Clouard

Meunier-Salaün

Val‐Laillet

2012

Animal

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The establishment of food preferences and aversions determines the modulation of eating behaviour and the optimization of food intake. These phenomena rely on the learning and memory abilities of the organism and depend on different psychobiological mechanisms such as associative conditionings and sociocultural influences. After summarizing the various behavioural and environmental determinants of the establishment of food preferences and aversions, this paper describes several issues encountered in human nutrition when preferences and aversions become detrimental to health: development of eating disorders and obesity, aversions and anorexia in chemotherapy-treated or elderly patients and poor palatability of medical substances and drugs. Most of the relevant biomedical research has been performed in rodent models, although this approach has severe limitations, especially in the nutritional field. Consequently, the final aim of this paper is to discuss the use of the pig model to investigate the behavioural and neurophysiological mechanisms underlying the establishment of food preferences and aversions by reviewing the literature supporting analogies at multiple levels (general physiology and anatomy, sensory sensitivity, digestive function, cognitive abilities, brain features) between pigs and humans.Keywords: pig, conditioned learning, eating behaviour, animal model, biomedical applications ImplicationsInvestigation of the behavioural and neurophysiological mechanisms of the establishment of food preferences and aversions can lead to important developments in the context of human nutrition and health. Because the rodent models are not always adequate in this field, there is a need to develop alternative experimental models. Pigs have numerous similarities with humans in terms of the physiology, anatomy, sensory sensitivity, cognitive abilities and brain functions. The aim of this paper is to promote the use of pigs for biomedical research in human nutrition. IntroductionFeeding is a complex behaviour, which can be described as 'the research and consumption of food and drink to maintain vital functions ' (Bellisle, 1999) and to 'fulfil the metabolic needs of the organism ' (Ferreira, 2004). Today, it is also well acknowledged that a high proportion of human food consumption in developed countries appears to be driven by pleasure (for a review, see Lowe and Butryn, 2007) and sociocultural influences. Food consumption is also involved in fundamental metabolic homeostasis regulation, as it controls the supply of energy and nutrients in the organism (Bellisle, 1999). According to Ferreira (2004), feeding behaviour implies that animals learn to consume high-energy foods and to avoid toxic foods. Establishment of food selection implies that, during its first experience with food, the organism memorizes the sensorial characteristics of the food (e.g. taste, odour, texture and visual cues) and the postingestive consequences of its ingestion, and associates these food characteristics with these consequences (Garcia et ...

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Section: Neurobiological Similaritiesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Clouard

Meunier-Salaün

Val‐Laillet

2012

Animal

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“…An additional obstacle of structural analysis in the neonatal pig brain is the lack of a brain atlas specific to this age. Currently, the only MRI-based atlas for the pig is in adult animals, which is not suitable for neonatal brain analysis (27). Because there is currently no atlas available for pigs during the neonatal period, we chose to use manual segmentation for volume analysis.…”

Section: Resultsmentioning

confidence: 99%

Magnetic resonance imaging of the neonatal piglet brain

et al. 2011

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ArticlesTranslational Investigation nature publishing group INTRODUCTION: appeal for the domestic pig as a preclinical model for neurodevelopmental research is increasing. One limitation, however, is lack of magnetic resonance imaging (MRI) methods for brain volume quantification in the neonatal piglet. The purpose of this study was to develop and validate MRI methods for estimating brain volume in piglets. RESULTS:The results showed that MRI and manual segmentation reliably estimated the changes in volume of different brain regions in 2-and 5-wk-old piglets. substantial increases in the volumes of all brain regions examined were evident during the 3-wk period. DISCUSSION: MRI can provide accurate estimates of brain region volume during the neonatal period in piglets. a piglet model that can be used in longitudinal studies may be useful for investigating how experimental (e.g., nutrition, infection) factors affect brain growth and development. METHODS: anatomic MRI data (non-longitudinal) were acquired from 2-and 5-wk-old piglets using a three-dimensional T1-weighted magnetization-prepared gradient echo (MPRaGe) sequence on a MaGNeTOM Trio 3T imager. Manual segmentation was performed for volume estimates of total brain, cortical, diencephalon, brainstem, cerebellar, and hippocampal regions. The MRI-based hippocampal volume estimates in 2-wk and 5-wk old piglets were validated using histological techniques and the cavalieri method.

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Resting‐state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain

et al. 2019

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IntroductionWhile the clinical efficacy of deep brain stimulation (DBS) the treatment of motor‐related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive.MethodsBy combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood‐oxygenation‐level‐dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model.ResultsWe found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter‐regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the strength of the inter‐regional resting‐state functional connectivity.ConclusionsNucleus accumbens stimulation affects the functional activity in networks that underlie cognition and behavior. Our study provides an insight into the nature of the functional connectivity, which mediates activation effect via brain networks.

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A three-dimensional digital segmented and deformable brain atlas of the domestic pig

Cited by 149 publications

References 30 publications

Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?

Magnetic resonance imaging of the neonatal piglet brain

Resting‐state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain

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