A three-dimensional histological atlas of the human basal ganglia. II. Atlas deformation strategy and evaluation in deep brain stimulation for Parkinson disease

Abstract

Object. The localization of any given target in the brain has become a challenging issue because of the increased use of deep brain stimulation to treat Parkinson disease, dystonia, and nonmotor diseases (for example, Tourette syndrome, obsessive compulsive disorders, and depression). The aim of this study was to develop an automated method of adapting an atlas of the human basal ganglia to the brains of individual patients.Methods. Magnetic resonance images of the brain specimen were obtained before extraction from the skull and histological processing. Adaptation of the atlas to individual patient anatomy was performed by reshaping the atlas MR images to the images obtained in the individual patient using a hierarchical registration applied to a region of interest centered on the basal ganglia, and then applying the reshaping matrix to the atlas surfaces.Results. Results were evaluated by direct visual inspection of the structures visible on MR images and atlas anatomy, by comparison with electrophysiological intraoperative data, and with previous atlas studies in patients with Parkinson disease. The method was both robust and accurate, never failing to provide an anatomically reliable atlas to patient registration. The registration obtained did not exceed a 1-mm mismatch with the electrophysiological signatures in the region of the subthalamic nucleus.Conclusions. This registration method applied to the basal ganglia atlas forms a powerful and reliable method for determining deep brain stimulation targets within the basal ganglia of individual patients. (DOI: 10.3171/2008.3.17469) kEy

Imaging insights into basal ganglia function, Parkinson's disease, and dystonia

“…The territories are represented using postmortem atlas coregistered to the T1-weighted image of the brain of a control patient as described in Bardinet and colleagues. 17 Territories in the substantia nigra are not represented (grey). The top figures show the significant areas of striatal dopamine release during gambling compared with control task in patients with Parkinson's disease (PD) with pathological gambling (PG; A) and without pathological gambling (B) in the ventral striatum (lower figure) and dorsal striatum (upper figure).…”

Functional Parcellation of the Lateral Mesencephalus

“…These results confirm the specific functional involvement of each MLR cluster in both tasks. Figure 2 shows the MRI parcellation of the human lateral mesencephalus with CN and PPN superimposed using a deformable 3D anatomical atlas Bardinet et al, 2009). …”

Automated Optimization of Subcortical Cerebral MR Imaging−Atlas Coregistration for Improved Postoperative Electrode Localization in Deep Brain Stimulation

“…Recently, automated registration of atlas MR imaging data of a brain specimen and the corresponding histologic section to individual MR imaging (atlas-to-patient) was shown to be robust and accurate. [26][27][28] These methods permit registration of MR imaging data with a specific atlas space, which is based on a few individuals (postmortem print atlases) with detailed but individual anatomic measures. However, a more standardized population-based stereotactic space would be advantageous to account for broad anatomic variety 4,5 and enable quantitative reference to points within anatomic structures or substructures.…”