“…A number of approaches have been developed to overcome these problems, the most successful of which involve the use of large gradients to overcome the broad linewidths [5,6], or use pure phase-encoded acquisition with modest gradient strengths [7]. Techniques employing very strong magnetic field gradients include: stray field imaging (STRAFI), which uses the very large static magnetic field gradient present in the fringe field of a superconducting magnet, together with repeated acquisitions between which the sample is moved or the magnetic field or RF frequency is adjusted, to determine the spin density of successive slices through the sample [5,8]; and the oscillating gradient technique, which incorporates the gradient coils within a resonant circuit, so that modest gradient strengths can be obtained relatively easily [6,9,10]. The single point imaging technique (SPI, or its variant SPRITE, single-point ramped imaging with T 1 enhancement) is a pure phase-encoding method, which acquires a single data sample at a fixed time after the application of an RF pulse, and repeats this as the gradient is incremented [7,11,12].…”