A three-temperature model of selective photothermolysis for laser treatment of port wine stain containing large malformed blood vessels

Li, D.; Wang, Guoxiang; He, Ya‐Ling; Wu, Wenjuan; Chen, Biao

doi:10.1016/j.applthermaleng.2013.12.042

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…In this case, the absorption of laser energy and the conduction/ convection between the chromophores and the surrounding tissue should be considered. As for the REV shown in Figure 2 according to the volume-averaging method of the porous medium (Badruddin et al, 2017), the local thermal non-equilibrium two-temperature heat transfer model of the porous medium with heat source can be deduced as follows (Li and Wang 2014):…”

Section: Biological Heat Transfer Modelmentioning

confidence: 99%

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Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model

Chen

Zhao

2019

HFF

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Purpose This paper aims to understand the laser–tissue interaction mechanism during ophthalmic laser surgeries through numerical analysis. The influence of laser parameters and the multipulse technique were investigated. Design/methodology/approach The ocular fundus was simplified as a multilayered homogenous medium model. Afterward, the multilayer Monte Carlo method was used to simulate the propagation and energy deposition of laser light, and a local thermal non-equilibrium two-temperature model was established to simulate the temperature variation of chromophores and surrounding tissue with different laser wavelength. Findings Through the model, the selective heating of chromophore (melanin and blood vessels) was clearly illustrated: 1) neglecting the laser energy absorbance by blood in the traditional model will cause significant errors in temperature calculation; 2) the non-thermal equilibrium heat transfer model was needed to obtain an accurate description of the thermal process when the dimensionless pulse width (tp*) is <105. For 532 nm Argon laser, the optimize tp* is around 105 and the appropriate energy density is 5 J/cm2; 3) multipulse technique makes the energy more concentrated within the melanin, thereby reducing the thermal damage in surrounding tissue, with most appropriate pulse number and duty cycle is 10 and 1/10. Originality/value Taking the blood absorption into account, the different temperature variations of melanin/vessels and surrounding tissue caused by the selective photo-thermolysis were simulated successfully. By understanding the mechanism of laser therapy, laser parameters and multipulse technique are suggested to improve the clinical results.

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Section: Biological Heat Transfer Modelmentioning

confidence: 99%

“…To our knowledge, there are no available results on the temperature distribution of the fundus tissue under local thermal non-equilibrium assumption. To verify the validation of our model, it was implemented to the simulation of temperature distribution in the laser skin surgery (Li and Wang, 2014).…”

Section: Model Verificationmentioning

confidence: 99%

Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model

Chen

Zhao

2019

HFF

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“…Recently, significant advances were achieved in the development of mathematical modeling methods of photothermal effects of nanoparticles (NPs) in tissues and cells [ 8 , 9 ]. It was shown that local inhomogeneities of the temperature fields lead to new laws of the distribution and dynamics of the Arrhenius damage integral [ 10 , 11 ], which provide a more appropriate selection of nanoparticle dimension and light exposure to gain precise control of hyperthermia with minimal energy consumption.…”

Section: Introductionmentioning

confidence: 99%

Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles

Bucharskaya

Maslyakova

Terentyuk

et al. 2016

IJMS

122

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Gold nanoparticles (AuNPs) of different size and shape are widely used as photosensitizers for cancer diagnostics and plasmonic photothermal (PPT)/photodynamic (PDT) therapy, as nanocarriers for drug delivery and laser-mediated pathogen killing, even the underlying mechanisms of treatment effects remain poorly understood. There is a need in analyzing and improving the ways to increase accumulation of AuNP in tumors and other crucial steps in interaction of AuNPs with laser light and tissues. In this review, we summarize our recent theoretical, experimental, and pre-clinical results on light activated interaction of AuNPs with tissues and cells. Specifically, we discuss a combined PPT/PDT treatment of tumors and killing of pathogen bacteria with gold-based nanocomposites and atomic clusters, cell optoporation, and theoretical simulations of nanoparticle-mediated laser heating of tissues and cells.

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Efficacy evaluation and treatment parameter optimization for laser surgery of Ota’s nevus based on an advanced non-equilibrium bio-tissue heat transfer model

Tian

Chen

2021

Lasers Med Sci

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A three-temperature model of selective photothermolysis for laser treatment of port wine stain containing large malformed blood vessels

Cited by 11 publications

References 26 publications

Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model

Numerical simulation of ophthalmic laser surgeries by a local thermal non-equilibrium two-temperature model

Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles

Efficacy evaluation and treatment parameter optimization for laser surgery of Ota’s nevus based on an advanced non-equilibrium bio-tissue heat transfer model

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