A Three-Year Follow-Up Study of Infection with Trypanosoma Cruzi and Electrocardiographic Abnormalities in a Rural Community in Northeast Brazil *

Maguire, James H.; Mott, K. E.; Hoff, Rodney; Guimarães, Ana Beatriz Giles; Franca, J T; Souza, J. A. A.; Ramos, Nilson Borges; Sherlock, Ítalo Rodrigues de Araújo

doi:10.4269/ajtmh.1982.31.42

Cited by 26 publications

(14 citation statements)

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“…The infectiousness of people seropositive for T. cruzi ranged from 2 to 3% to 26% and declined significantly with age (Maguire et al 1982). In contrast, the mean infectiousness of naturally infected, seropositive dogs (45-57%) was loosely or not related to age and was positively associated with the domiciliary density of T. infestans infected with T. cruzi (Gürtler et al 1992a(Gürtler et al , 1996.…”

Section: Introductionmentioning

confidence: 80%

Domestic dogs and cats as sources ofTrypanosoma cruziinfection in rural northwestern Argentina

et al. 2006

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SUMMARYThe reservoir capacity of domestic cats and dogs for Trypanosoma cruzi infection and the hostfeeding patterns of domestic Triatoma infestans were assessed longitudinally in 2 infested rural villages in north-western Argentina. A total of 86 dogs and 38 cats was repeatedly examined for T. cruzi infection by serology and/or xenodiagnosis. The composite prevalence of infection in dogs (60%), but not in cats, increased significantly with age and with the domiciliary density of infected T. infestans. Dogs and cats had similarly high forces of infection, prevalence of infectious hosts (41-42%), and infectiousness to bugs at a wide range of infected bug densities. The infectiousness to bugs of seropositive dogs declined significantly with increasing dog age and was highly aggregated. Individual dog infectiousness to bugs was significantly autocorrelated over time. Domestic T. infestans fed on dogs showed higher infection prevalence (49%) than those fed on cats (39%), humans (38%) or chickens (29%) among 1085 bugs examined. The basic reproduction number of T. cruzi in dogs was at least 8·2. Both cats and dogs are epidemiologically important sources of infection for bugs and householders, dogs nearly 3 times more than cats.

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Section: Introductionmentioning

confidence: 80%

Domestic dogs and cats as sources ofTrypanosoma cruziinfection in rural northwestern Argentina

et al. 2006

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“…Also, the percentage of seropositive individuals with detectable parasitemia has been reported to decline with age. 17,18 Given the high prevalence of seropositivity among children in Loja, seropositive persons here likely have higher levels of parasitemia than seropositive persons in Manabí and Guayas, who are on average older and may have been infected for several decades. Thus, persons in Loja could be more infective to the triatomine vectors when bitten, and prevalence of T. cruzi infection in the vector population is more likely to be associated with human infections here than in the coastal regions, where rodents and domestic animals are probably more important sources of infection for the vectors.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Trypanosoma cruzi in Rural Ecuador and Clustering of Seropositivity within Households

Black¹,

Ocaña-Mayorga²,

Riner³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. We performed a cross-sectional study of Trypanosoma cruzi seroprevalence in 14 communities in three provinces of Ecuador and estimated the magnitude of the association of seropositive individuals within households. A total of 3,286 subjects from 997 households were included. Seroprevalence was 5.7%, 1.0%, and 3.6% in subjects in the Manabí, Guayas, and Loja provinces, respectively. Seroprevalence increased with increasing age in Manabí and Guayas, whereas in Loja, the highest prevalence occurred in children ≤ 10 years of age. In the coastal provinces, clustering of seropositives within households was not observed after adjustment for other household factors. However, in the Andean province of Loja, the odds of seropositivity were more than two times greater for an individual living in a household with another seropositive person. Our results indicate that transmission of T. cruzi is ongoing in Ecuador, although intensity of transmission and mechanisms of interaction between humans and the insect vectors of disease vary between geographic regions.

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“…ECGs were recorded in 12 standard derivations using a portable Hewlett Packard electrocardiograph. Two physician doctors coded each tracing (without serological information of the cases) according to the classification previously proposed and discrepancies were resolved by mutual agreement (Maguire et al 1982). The ECG's showing atrioventricular block (AVB), incomplete and complete right bundle branch block (IRBBB and CRBBB), left anterior hemiblock (LAH), multifocal ventricular extrasystole (MVE), or junctional rhythm (JR) were considered abnormal.…”

Section: Methodsmentioning

confidence: 99%

Integrate Study of a Bolivian Population Infected by Trypanosoma cruzi, the Agent of Chagas Disease

Brenière

Noireau

Yacsik

et al. 2002

Mem. Inst. Oswaldo Cruz

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A Three-Year Follow-Up Study of Infection with Trypanosoma Cruzi and Electrocardiographic Abnormalities in a Rural Community in Northeast Brazil *

Cited by 26 publications

References 0 publications

Domestic dogs and cats as sources ofTrypanosoma cruziinfection in rural northwestern Argentina

Domestic dogs and cats as sources ofTrypanosoma cruziinfection in rural northwestern Argentina

Seroprevalence of Trypanosoma cruzi in Rural Ecuador and Clustering of Seropositivity within Households

Integrate Study of a Bolivian Population Infected by Trypanosoma cruzi, the Agent of Chagas Disease

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