Owing to map scale reduction and other cartographic generalization operations, spatial conflicts may occur between buildings and other features in automatic cartographic generalization. Displacement is an effective map generalization operation to resolve these spatial conflicts to guarantee map clarity and legibility. In this paper, a novel building displacement method based on multipopulation genetic algorithm (BDMPGA) is proposed to resolve spatial conflicts. This approach introduces multiple populations with different control parameters for simultaneous search optimization and adopts an immigration operation to connect different populations to realize coevolution. The optimal individuals of each population are selected and preserved in the elite population through manual selection operation to prevent the optimal individuals from being destroyed and lost in the evolutionary process. Meanwhile, the least preserving generation of the optimal individuals is used as the termination basis. To validate the proposed method, urban building data with a scale of 1:10,000 from Shenzhen, China are used. The experimental results indicate that the method proposed in this paper can effectively resolve spatial conflicts to obtain better results.