A time course study of high on treatment platelet reactivity in acute coronary syndrome male patients on dual antiplatelet therapy

Fabbri, Alessia; Marcucci, Rossella; Gori, Anna Maria; Giusti, Betti; Paniccia, Rita; Balzi, Daniela; Barchielli, Alessandro; Valente, Serafina; Giglioli, Cristina; Abbate, Rosanna; Gensini, Gian Franco

doi:10.1016/j.thromres.2015.06.040

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Consistent with this, a higher platelet turnover, as indicated by higher levels of reticulated platelets, was associated with resistance to antiplatelet therapy with ASS [94]. Higher levels of reticulated platelets also correlated with resistance to anti-platelet therapy with clopidogrel [95], prasugrel [96,97] and to dual antiplatelet therapy with ASS/thienopyridine [80,[98][99][100][101]. Hypo-responsiveness to clopidogrel (aggregation >50% in response to ADP) in healthy individuals was associated with high numbers immature platelets (upper tertile) and an IPF ≥ 3.6% identified subjects with an impaired response to clopidogrel with a sensitivity and specificity of 85.7% and 81.8%, respectively [95].…”

Section: Antiplatelet Therapymentioning

confidence: 75%

Reticulated platelets – clinical application and future perspectives

Meintker

Krause

2020

Journal of Laboratory Medicine

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Reticulated platelets are immature platelets freshly released from the bone marrow into the circulation and contain vestigial amounts of ribonucleic acid. Thus, they can serve as an indicator for the activity of thrombopoiesis. Despite the current lack of a standardized reference method, two types of hematology analyzers have incorporated a fully automated measurement of reticulated platelets. The “immature platelet fraction” (IPF; Sysmex XE-/XN-series) has some clinical utility in the differential diagnosis of thrombocytopenia. This is less clear for “reticulated platelets” (retPLT; Abbott CELL-DYN Sapphire/Alinity HQ). The usefulness of these parameters in the prediction of platelet recovery after chemotherapy or stem cell transplantation and as a decision aid for platelet transfusions has not been unequivocally confirmed. Recent findings have shown an association of reticulated platelets with an adverse risk in patients with coronary artery disease and stroke as well as resistance to anti-platelet therapy. Furthermore, a role of reticulated platelets for the prediction of sepsis was indicated. However, validation in larger prospective trials is necessary to establish the clinical benefit of reticulated platelets in these conditions. This review gives an overview of the available analytical methods and summarizes the current knowledge regarding the clinical application of reticulated platelets.

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Section: Antiplatelet Therapymentioning

confidence: 75%

Reticulated platelets – clinical application and future perspectives

Meintker

Krause

2020

Journal of Laboratory Medicine

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“…The study group concluded that late HPR presented by an elevated level of IPF is most likely correlated with inflammation [35].…”

Section: Ipf In Therapy For Acute Coronary Syndromementioning

confidence: 99%

“…Furthermore, IPF was the only variable that correlated with late HPR (p = 0.016). The study group concluded that late HPR presented by an elevated level of IPF is most likely correlated with inflammation [ 35 ].…”

Section: Ipf In Therapy For Acute Coronary Syndromementioning

confidence: 99%

Immature platelet fraction in cardiovascular diagnostics and antiplatelet therapy monitoring

et al. 2023

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Immature platelet fraction (IPF), circulating platelets still containing RNA, can be easily calculated by automated flow cytometry, this makes them an accessible biomarker. Higher IPF concentrations were reported in patients with thrombocytopenia, patients who were smokers, and also those who were diabetics. Several studies have reported their diagnostic and prognostic importance in patients presenting with acute coronary syndromes, especially ST-segment myocardial infarction, where increased IPF level is an independent predictor of cardiovascular death. In addition, higher IPF were reported in patients with inadequate response to either clopidogrel or prasugrel, suggesting their potential role in antiplatelet therapy monitoring. Their prognostic significance was also observed in both coronary artery disease and postcardiac surgery status, where their higher levels correlated with the risk of major adverse cardiac events.The present review aims to present the current evidence on diagnostic, prognostic and potentially therapeutic roles of IPF in cardiovascular medicine.

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