To solve the problem of secondary path mutation and external disturbance abrupt changes during helicopter maneuver flight, the previous research proposed a hybrid active vibration control law. To improve the engineering applicability, the original algorithm is ameliorated to the least mean square-input-output-based robust (LMS-IOBR) algorithm. The system model within the target frequency band can be identified through the input-output data to avoid constructing complex state observers. In addition, the output form of the feedback controller is constructed by an autoregressive moving average model with extra input, which is beneficial to improve operational efficiency. Numerical simulations demonstrate that compared with the original algorithm, controller real-time computation can be reduced by 52% with control effects guaranteed at the same time. Furthermore, to verify the effectiveness and adaptability of LMS-IOBR, multi-input multioutput vibration control experiments are carried out on a specially developed simple platform for simulating helicopter maneuver states. Comparative tests in various typical states are performed between the LMS-IOBR and the multichannel least mean square algorithm. Under the complex circumstances of simulating continuous subduction uplift, the peak response of closed-loop system attenuates by 80% and 70%, and the vibration of two points is reduced to 15% and 20%, respectively, within 3 s. The experimental results demonstrate that the proposed LMS-IOBR algorithm shows stronger transient adaptability and robustness against external disturbance excitation and secondary channel mutation in helicopter maneuver flight.