ABSTRACT:With the further increase of span of spatial structures, wind load becomes one of the governing factors in structural design. Attention is paid to wind-induced response analysis of spatial grid structures in the recent years. Research on the wind-induced responses of the cylindrical reticulated mega-structure with double-layer plane-plate grid substructures is conducted by time-history method in this paper. The basic distribution laws of the wind-induced member internal forces and nodal displacements of both the main structure and substructures are first analyzed. By detailed parametric analyses, the effect of the geometric parameters, damping ratio, load, boundary condition, and wind velocity on structural wind-induced response is then studied. Finally the structural wind-induced vibration coefficients are analyzed, and their rational values are recommended. All this work will provide theoretical guidance to the wind-resistance design of this kind of structure.