When a surface effect ship (SES) sails in waves, the unsteady velocity potential of water can be decomposed into incident potential, sidehull radiation potential, sidehull diffraction potential and radiation potential due to fluctuating air pressure. The potentials related to sidehulls satisfy Neumann boundary conditions (BC) and have been successfully addressed using the 2.5D method. In contrast, the potential related to fluctuating air pressure satisfies mixed BC consisting of homogeneous Neumann BC on the wetted surface of sidehulls and nonhomogeneous Dirichlet BC on the interface between air and water, which has never been studied using the efficient 2.5D method. In this paper, the 2.5D method is firstly proposed to solve the mixed boundary value problem (BVP), which can deal with the coupling between the fluctuating air pressure and sidehulls. By using the 2.5D method, the radiation wave and other relative hydrodynamic parameters of a SES due to the fluctuating air pressure are evaluated. The numerical results on motion response and the fluctuated air pressure of the SES show acceptable agreement with the experimental ones.