SAE Technical Paper Series 2003
DOI: 10.4271/2003-22-0006
|View full text |Cite
|
Sign up to set email alerts
|

A Tissue Level Tolerance Criterion for Living Brain Developed with an In Vitro Model of Traumatic Mechanical Loading

Abstract: Traumatic brain injury (TBI) is caused by brain deformations resulting in the pathophysiological activation of cellular cascades which produce delayed cell damage and death. Understanding the consequences of mechanical injuries on living brain tissue continues to be a significant challenge. We have developed a reproducible tissue culture model of TBI which employs organotypic brain slice cultures to study the relationship between mechanical stimuli and the resultant biological response of living brain tissue. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

11
134
1

Year Published

2006
2006
2020
2020

Publication Types

Select...
6
3

Relationship

1
8

Authors

Journals

citations
Cited by 121 publications
(146 citation statements)
references
References 38 publications
11
134
1
Order By: Relevance
“…There is evidence from in vitro experiments that strains of 5-8% induce a wide range of biological effects in neural cells. 6,10,16,18 Considering that the model with median scleral stiffness properties showed an ONH biomechanical environment closer to the stiff scenario than to the compliant scenario (Figs. 4-6), we conclude that IOP-induced deformation dramatically increases in eyes that belong to the lower range of physiologic scleral stiffness (''weak'' scleras).…”
Section: Discussionmentioning
confidence: 97%
“…There is evidence from in vitro experiments that strains of 5-8% induce a wide range of biological effects in neural cells. 6,10,16,18 Considering that the model with median scleral stiffness properties showed an ONH biomechanical environment closer to the stiff scenario than to the compliant scenario (Figs. 4-6), we conclude that IOP-induced deformation dramatically increases in eyes that belong to the lower range of physiologic scleral stiffness (''weak'' scleras).…”
Section: Discussionmentioning
confidence: 97%
“…The impulses were applied to the skull of the models in the sagittal plane. The results from these simulations, conducted in LS-DYNA (Livermore Software Technology Corporation, 2003) were compared in terms of maximum principal Green Lagrange strain that served as a predictor of central nervous system (CNS) injury since it has been shown to correlate with DAI (Bain and Meaney, 2000) as well as cell death and neuronal dysfunction (Morrision et al, 2003).…”
Section: Methodsmentioning
confidence: 99%
“…In recent years, there have been numerous experimental studies aimed at defining injury thresholds for the functional damage of neural cells (Bain and Meaney 2000;Elkin and Morrison III 2007;Geddes and Cargill 2001;Morrison et al 2003;Wolf et al 2001). These injury thresholds are measures of stress or strain at either the cellular or tissue level.…”
Section: Axonal Strain Injury Criterionmentioning
confidence: 99%