2018
DOI: 10.1016/j.gep.2018.10.003
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A tissue-specific enhancer of the C. elegans nhr-67/tailless gene drives coordinated expression in uterine stem cells and the differentiated anchor cell

Abstract: The nhr-67 nuclear receptor gene of Caenorhabditis elegans encodes the ortholog of the Drosophila tailless and vertebrate Tlx genes. In C. elegans, nhr-67 plays multiple roles in the development of the uterus during L2 and L3 larval stages. Four pre-VU cells are born in the L2 stage and form the precursor complement for the ventral surface of the mature uterus. One of the four pre-VU cells becomes the anchor cell (AC), which exits the cell cycle and differentiates, while the remaining three VU cells serve as s… Show more

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Cited by 10 publications
(18 citation statements)
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“…8). Our model fits with data by others showing 495 that hlh-2 may directly bind to the nhr-67 promoter through two canonical E-box motifs 496 found in a 164 bp window in a functional promoter element deleted in several 497 hypomorphic alleles of nhr-67 (Bodofsky et al, 2018;Matus et al, 2015;Verghese et 498 al., 2011). Further, deletion of these hlh-2 conserved binding sites results in loss of AC-499 specific GFP expression in transgenic lines (Bodofsky et al, 2018).…”
supporting
confidence: 84%
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“…8). Our model fits with data by others showing 495 that hlh-2 may directly bind to the nhr-67 promoter through two canonical E-box motifs 496 found in a 164 bp window in a functional promoter element deleted in several 497 hypomorphic alleles of nhr-67 (Bodofsky et al, 2018;Matus et al, 2015;Verghese et 498 al., 2011). Further, deletion of these hlh-2 conserved binding sites results in loss of AC-499 specific GFP expression in transgenic lines (Bodofsky et al, 2018).…”
supporting
confidence: 84%
“…Our model fits with data by others showing 495 that hlh-2 may directly bind to the nhr-67 promoter through two canonical E-box motifs 496 found in a 164 bp window in a functional promoter element deleted in several 497 hypomorphic alleles of nhr-67 (Bodofsky et al, 2018;Matus et al, 2015;Verghese et 498 al., 2011). Further, deletion of these hlh-2 conserved binding sites results in loss of AC-499 specific GFP expression in transgenic lines (Bodofsky et al, 2018). While others have 500 also reported positive regulation by EGL-43 on nhr-67 activity via transgenic reporters 501 (Bodofsky et al, 2018), this interaction, and many of the others TF interactions, may be 502 indirect, as no known binding sites exist for EGL-43 in the nhr-67 promoter.…”
supporting
confidence: 84%
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“…HLH-2 independently regulates cdh-3 along with other targets and cytoskeletal polarity (Schindler and Sherwood, 2011). Prior work has also suggested that EGL-43 and HLH-2 may regulate NHR-67 based on conserved HLH-2 binding motifs present in the nhr-67 promoter as well as perturbation experiments using nhr-67 transgenic reporters (Bodofsky et al, 2018;Verghese et al, 2011). Interestingly, three of these TFs (egl-43, hlh-2 and nhr-67) also play key roles in the specification of the AC and VU cell fates during the L2 stage (Attner et al, 2019;Hwang et al, 2007;Karp and Greenwald, 2004;Sallee et al, 2017;Verghese et al, 2011).…”
Section: Introductionmentioning
confidence: 99%