A Topological Model of Dna Replication With Dna-Links

Mohamad, Abdul Adheem; Yashiro, Tsukasa

doi:10.17654/ms107010241

Cited by 1 publication

(6 citation statements)

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“…This relaxation does not require the counter rotation. This is different from the topological model proposed in [5]. The next problem to solve is to know how many times TopoIA should be applied to change the crossings during the replication in the replicon.…”

Section: B Recursive Unknotting Operationsmentioning

confidence: 95%

“…From this observation, the authors described in [5] that the semi-conservative scheme is interpreted in terms of DNA-links as:…”

Section: A Dna-linkmentioning

confidence: 99%

“…The replicon (loop) is modeled by the 2-component tangle (link) shown in Figure 2 (c). We described a topological model for DNA replication in [5] but it requires some over twist absorbing mechanisms which are unknown. If the process described in this section is used in the replication model, then the over twisting absorbing mechanism is not needed.…”

Section: A Rewinding Model For Repliconsmentioning

confidence: 99%

“…If the process described in this section is used in the replication model, then the over twisting absorbing mechanism is not needed. The model in this section can be a solution for the problem unsolved in [5].…”

Section: A Rewinding Model For Repliconsmentioning

confidence: 99%

“…This model can reduce the twisting number of the DNA-link efficiently. The recursive unknotting operation resolve the unsoloved problem in [5].…”

Section: Introductionmentioning

confidence: 99%

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A rewinding model for replicons with DNA-links

Mohamad

Yashiro

2020

BIOMATH

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A double strand DNA has a double helical structure and it is modeled by a thin long twisted ribbon fixed at the both ends. A DNA-link is a topological model of such a DNA segment in the nuclear of a eukaryotic cell. In the cell cycle, the DNA is replicated and distributed into new cells. The complicated replication process follows the semi-conservative scheme in which each backbone string is preserved in the replicated DNA. This is interpreted in terms of splitting process of the DNA-link. In order to split the DNA-link, unknotting operations are required. This paper presents a recursive unknotting operations, which efficiently reduce the number of twistings.

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Section: B Recursive Unknotting Operationsmentioning

confidence: 95%

“…From this observation, the authors described in [5] that the semi-conservative scheme is interpreted in terms of DNA-links as:…”

Section: A Dna-linkmentioning

confidence: 99%

Section: A Rewinding Model For Repliconsmentioning

confidence: 99%

Section: A Rewinding Model For Repliconsmentioning

confidence: 99%

“…This model can reduce the twisting number of the DNA-link efficiently. The recursive unknotting operation resolve the unsoloved problem in [5].…”

Section: Introductionmentioning